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Clinical Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment

research Clinical Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment

June 2024 in “Research Square (Research Square)”

Young women in West Bengal, India, with PCOS often have estrogen resistance, leptin receptor issues, folate deficiency, T2DM, and acanthosis, commonly linked to obesity.

research The Polycystic Ovary Syndrome: A Position Statement from the European Society of Endocrinology

467 citations, October 2014 in “European Journal of Endocrinology”

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Ethnicity, Obesity, and the Prevalence of Impaired Glucose Tolerance and Type 2 Diabetes in PCOS: A Systematic Review and Meta-Regression

research Ethnicity, Obesity, and the Prevalence of Impaired Glucose Tolerance and Type 2 Diabetes in PCOS: A Systematic Review and Meta-Regression

189 citations, March 2018 in “Human Reproduction Update”

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

research Diabetes and Cardiovascular Events in Women with Polycystic Ovary Syndrome: A 20-Year Retrospective Cohort Study

150 citations, October 2012 in “Clinical Endocrinology”

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

research Targeting the Pre-Receptor Metabolism of Cortisol as a Novel Therapy in Obesity and Diabetes

70 citations, March 2010 in “The Journal of Steroid Biochemistry and Molecular Biology”

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

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community 2 years on .5mg Finasteride/day

in Progress Pictures 120 upvotes 5 months ago

A user shared progress pictures after 2 years on 0.5mg finasteride daily, also using minoxidil, showing significant hair improvement. The user noted their hairline is almost fully recovered.

community Alfatradiol is a topical 5AR inhibitor that this study shows is effective in stopping hair loss without sides. It can be bought OTC in Europe right now. Thoughts?

13 upvotes 8 years ago

Hair loss treatments, specifically the use of Alfatradiol as an over-the-counter topical 5AR inhibitor that has been shown to be effective in stopping hair loss without side effects. Other treatments discussed include Minoxidil, finasteride and RU58841.

community What treatment helps diffuse hair thinning from insulin resistance?

in Treatment 1 upvotes 1 year ago

The individual is experiencing hair loss due to insulin resistance (IR) and is seeking advice. They are currently using a keto diet, supplements, exercise, and plan to add metformin to their regimen.

community When I was in my 20s, skinny and with long hair, one of my biggest fear was being fat and bald in my 40s. Now that it’s come to pass, I’ve found there are better things to worry about. I started shaving my head in 05 when I was 32 and I can sum it all up in one word: Liberating.

in Shaved/buzzed 478 upvotes 3 years ago

Accepting hair loss, with solutions discussed including Minoxidil and Finasteride treatments, shaving the head as a liberating experience, and using beards to make up for lack of hair.

community How do you stop hair loss in Aggressive diffuse loss that started in your teens?

in Chat 10 upvotes 7 months ago

The user is experiencing aggressive hair loss since their teens and has tried finasteride, topical minoxidil, dutasteride, and oral minoxidil without success in halting the hair loss. They are seeking advice on how to stop it.

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