Quantitative Imaging Biomarkers of PRP-Induced Tendon Remodeling in Chronic Tendinopathy: Review and Single-Center Experience with Ultrasound Radiomics and MRI T2 Profiling

This study suggests that platelet-rich plasma may improve pain and function in patients with partial-thickness rotator cuff tears and tendinopathy short-term, but the long-term benefits are unclear.

In this retrospective study at Lausanne University Hospital, 61% of 48 patients with tendinopathies reported favorable outcomes after a single standardized autologous PRP injection, while 36% needed two, and effectiveness was unrelated to platelet concentration, activity level, age, or gender.

This study found that a single dose of PRP with 100 billion platelets significantly reduced pain and improved knee function in patients with osteoarthritis, but did not alter joint structure on MRI.

This study found that, in male patients with patellar tendinopathy, bone marrow mesenchymal stromal cell treatment improved tendon regeneration, organization, strength, and pain relief more effectively than leukocyte-poor platelet-rich plasma over 12 months.

This review discusses the use of platelet-rich plasma for musculoskeletal pain relief and function improvement, but notes the current studies' limitations regarding methods and types of treatment.