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Cyclophosphamide: As Bad as Its Reputation? Long-Term Single Centre Experience of Cyclophosphamide Side Effects in the Treatment of Systemic Autoimmune Diseases

research Cyclophosphamide: As bad as its reputation? Long-term single centre experience of cyclophosphamide side effects in the treatment of systemic autoimmune diseases

39 citations , October 2014 in “Schweizerische medizinische Wochenschrift”

This study found that while cyclophosphamide remains effective for severe autoimmune conditions, it is associated with gastrointestinal side effects, infections, some cases of irreversible amenorrhoea, and a higher risk of malignancies, emphasizing the need for long-term monitoring.

research Potential PRP Hair Treatment Side Effects

February 2017

PRP hair treatment is generally safe but may cause minor pain, bleeding, redness, and scalp tightness, and isn't suitable for everyone.

research Glucocorticoid-Induced Side Effects Cause Oral Lesions in Systemic Lupus Erythematosus: A Case Report

November 2024 in “International Medical Case Reports Journal”

Glucocorticoid treatment in lupus can cause oral lesions, which need early diagnosis and comprehensive care.

research Systemic retinoids and thyrotoxicosis in (Multi) nodular goiter: Side effect or coincidence?

1 citations , January 2018 in “Indian Journal of Dermatology/Indian journal of dermatology”

This report describes cases of transient thyrotoxicosis potentially linked to oral retinoid treatment, suggesting a possible mechanism involving increased iodine uptake by thyroid cells.

research Central Centrifugal Cicatricial Alopecia: A Survey of Treatment Practices Among Dermatology Residents and Attending Physicians

September 2025 in “Cureus”

This study found that dermatologists in an urban academic setting most frequently use topical corticosteroids, intralesional corticosteroids, and topical minoxidil for treating central centrifugal cicatricial alopecia, aligning with current literature recommendations on reducing inflammation.

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community Mesotherapy Dutasteride Reverses Hair Loss. Most effective treatment we have in reducing scalp DHT

5 upvotes 2 years ago

Mesotherapy Dutasteride is considered highly effective for reducing scalp DHT and potentially reversing hair loss. However, one user reported systemic side effects and no improvement in hair loss.

community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

15 upvotes 5 months ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle

1 upvotes 1 year ago

The conversation discusses the need for a localized 5-alpha reductase inhibitor that only affects the scalp without systemic side effects, similar to pyrilutamide's approach. Current treatments like topical liposomal finasteride and dutasteride are mentioned, but concerns about their systemic effects and lack of research are highlighted.

community Wonder if anyone has tried not just Dutasteride, but the Dutasteride mesotherapy treatments?

3 upvotes 6 months ago

Dutasteride mesotherapy is discussed as a potential treatment for hair loss, with some users suggesting it offers a slight boost when combined with oral minoxidil, though it's costly. Concerns about side effects and systemic absorption are noted, with alternatives like topical dutasteride and microneedling suggested for home use.

community I think microneedling before topical application of finasteride (or dut) is a path we should investigate (for those of us who don't care about systemic absorption). Here's why...

20 upvotes 1 year ago

Microneedling before applying topical finasteride or dutasteride may enhance their effectiveness by increasing local absorption in the scalp, despite concerns about systemic absorption. Users discuss combining this method with oral treatments and minoxidil, noting potential benefits and side effects.

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