research Penetration and Distribution in Human Skin Focusing on the Hair Follicle
Targeting drugs to hair follicles can treat skin conditions, but reaching deep follicle areas is hard and needs more research.
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5 / 1000+ results research Medical comorbidities and sex distribution among patients with lichen planopilaris and frontal fibrosing alopecia: A retrospective cohort study
Women with lichen planopilaris and frontal fibrosing alopecia often have other health issues like hypothyroidism and lupus.
research Diffuse hair loss in a patient with systemic lupus erythematosus
This report describes a 57-year-old woman with fibrosing alopecia in a pattern distribution, who experienced hair regrowth with combined treatment including hydroxychloroquine and other topical and oral therapies.
research Key considerations of injectable minoxidil for alopecia
This source explores injectable minoxidil as a hair loss treatment, noting its enhanced bioavailability but also the potential for adverse effects and higher costs compared to other formulations, with a call for further research on its efficacy and access relative to alternatives.
research Hair loss in women
This article discusses the clinical features and treatment options for common types of hair loss in women and reports no new clinical results.
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5 / 1000+ resultscommunity Theory As To Why Oral Minoxidil Might Be Helpful To People Compared To Topical Minoxidil
Oral minoxidil may be more effective than topical due to uniform distribution and systemic activation, but can cause side effects like puffiness. Adding tretinoin to topical minoxidil can enhance its effectiveness by aiding conversion to its active form.
community If apply topical fin goes systemic then does it matter where I apply it on the scalp?
The conversation is about whether topical finasteride and minoxidil need to be applied directly to the affected areas of the scalp or if they can be spread through blood vessels. It also asks how long topical finasteride remains on a pillow.
community Napkin math: are we using 100x more topical finasteride than necessary?
Topical finasteride concentrations are likely much higher than necessary for effective follicular DHT suppression, with current standards being 100-1000 times above the theoretical minimum. Lower concentrations (0.001-0.0025%) might still work locally while minimizing systemic exposure.
community GT20029 Will Replace Finasteride For Hair Loss
GT20029 shows promise as a topical treatment for hair loss, potentially replacing finasteride for some due to its low systemic exposure and ability to degrade androgen receptors. However, skepticism remains about its long-term efficacy and availability, with some users expressing doubt about new treatments consistently failing to reach the market.
community The expected timeline for PP405 - Next update at AAD Annual Meeting in March 2026 ?
A new hair loss treatment, PP405, showed promising Phase 2a results with 31% of patients experiencing over 20% hair density increase without systemic absorption, avoiding hormonal side effects. The treatment is expected to be expensive, with Phase 3 trials starting mid-2026, and there is skepticism about the data's strength.
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2 / 801 results- Can follistatin be applied topically, or is it only effective through injections or systemic use? Follistatin is not effective when applied topically and requires injections or systemic use.
- Is Thymosin Beta 4 being explored more as a topical treatment or as a systemic (oral or injectable) approach for hair loss? Thymosin Beta 4 is primarily being explored as a topical treatment for hair loss.
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