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Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

16 citations , October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

research Topical antiandrogens in the treatment of male-pattern baldness

10 citations , October 1988 in “Clinics in dermatology”

This review discusses the potential of antiandrogens for androgen-induced baldness in men and women but reports no new clinical findings, emphasizing the need for further research on long-term risks and efficacy.

research Clascoterone: a new topical antiandrogen agent.

February 2025 in “Prospects in Pharmaceutical Sciences”

This source reports that clascoterone cream, a topical androgen receptor inhibitor, has shown effectiveness in treating facial acne vulgaris in patients 12 and older, with clinical trials indicating a favorable safety profile compared to systemic treatments, and potential for broader dermatological applications.

research Systemic treatment options for androgenic alopecia

March 2026 in “Lithuanian University of Health Sciences”

In this study, a systematic review found that for androgenetic alopecia, systemic treatments like finasteride, dutasteride, and oral minoxidil are effective at slowing progression and promoting hair regrowth, with additional antiandrogen therapy options for women.

research Anti-androgen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies

May 2025 in “Journal of the American Academy of Dermatology”

This review highlights the available and investigational anti-androgen treatments for female pattern hair loss in the US, noting their limitations and the potential for fewer systemic side effects with topical options compared to oral medications.

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community Which is safest carrier for topical antiandrogens (finasteride/kx-826/ru/dutasteride)

5 upvotes 8 months ago

The conversation is about finding a safe carrier for topical antiandrogens like finasteride, kx-826, RU58841, and dutasteride to minimize systemic absorption and side effects. The user experiences side effects from these treatments and is seeking advice on carriers that reduce these effects.

community M 26, had to cut my hair short for mandatory military service and I saw a lot more of my vertex than I was anticipating.

5 upvotes 4 years ago

The conversation discusses hair loss treatments, focusing on the anti-androgen component CB 03 01 and its systemic absorption and safety compared to finasteride. It highlights concerns about inhibiting DHT conversion and the safety of using clascoterone for hair loss.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 14 upvotes 1 year ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community For those that have used anti androgens what is your experience?

19 upvotes 2 years ago

People discussed their experiences with anti-androgens for hair loss, mentioning side effects like chest pains with RU58841 and skepticism due to lack of safety data, while considering Fluridil as a potential addition to treatment. Some users expressed reluctance to use these chemicals.

community I Get Side-Effects from Anti-Androgens

8 upvotes 6 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

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Learn

5 / 14 results

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

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Clinics

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All 77 clinic results →

Experts

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16
Dermatologist
Andi Iryanti, M. Biomed
Indonesia

Andi Iryanti, M. Biomed