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research HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment

24 citations , October 2018 in “Addiction Biology”

This study found that alcohol dependence is associated with altered HPA axis functioning, with AD patients showing higher hair cortisol concentrations and reduced ACTH and cortisol levels, irrespective of childhood maltreatment history.

research Hair Cortisol Concentrations in High- and Low-Stress Mother-Daughter Dyads

January 2015

This study found that hair cortisol concentrations in mother-daughter pairs are a potential biomarker for cortisol responses to chronic stress, with daughter-mother similarities affected by parenting styles and children's symptoms.

research Does hair cortisol concentration reflect measurable regulatory biology of the HPA axis in healthy humans?

February 2026 in “Psychoneuroendocrinology”

Hair cortisol concentration partly reflects HPA axis regulation but doesn't capture all its complexities.

research HPA Axis Variation and ACEs; Childhood Sexual Trauma is Associated with Lower Hair Cortisol in Adulthood

1 citations , June 2023 in “Psychoneuroendocrinology”

This study found that sexual trauma, particularly occurring between ages 5-7, was significantly associated with blunted hair cortisol levels, revealing a potential critical developmental stage affecting HPA axis function. No significant link was observed between cortisol reactivity and other adverse childhood experiences or stressors.

research Cutaneous manifestations of COVID-19 and vaccines for its prevention: a review of the existing literature

April 2026 in “Portuguese Journal of Dermatology and Venereology”

This review summarizes the various skin manifestations linked to COVID-19 infection, vaccination, and personal protective equipment, highlighting their clinical importance and discussing psychological stress and social isolation as additional dermatologic factors.

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community Possible regrowth after 4 years of hair loss (with family history of baldness) — could lifestyle changes reactivate follicles?

3 upvotes 5 months ago

The user noticed hair regrowth after 4 years of hair loss, coinciding with lifestyle improvements like quitting smoking, exercising, and a better diet. They are curious if dormant follicles can recover under improved conditions.

community Did UCLA Just Cure Baldness? Check this Out!

in Research/Science 968 upvotes 1 year ago

UCLA's PP405 shows promise in reactivating dormant hair follicles for hair loss treatment but is still in clinical trials. Minoxidil and finasteride remain common treatments until PP405 becomes available.

community Confused why people are calling PP405 a cure...it never claimed to be able to undo miniaturization or revert vellus back to terminal hairs. It seems to be more of a growth stimulant like minoxidil.

in Research/Science 55 upvotes 1 year ago

PP405 is not a cure for hair loss but may reactivate dormant hair follicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.

community GT20029 and PP405 the new fin and min that we been waiting for ?

36 upvotes 1 year ago

PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

community Forced to be 10 days without minox. My hair is preparing its final goodbye. Tell me it's not the end.

in Minoxidil 84 upvotes 1 year ago

Stopping minoxidil for 10 days due to eye surgery, with concerns about hair loss. Most responses suggest a short break won't significantly impact hair, and emphasize prioritizing eye health.

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Learn

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Lavender

Is lavender effective for hormonal hair loss or just stress? No study has tested lavender for stress-related or hormonal hair loss in people; the hair-growth evidence is one mouse study. Case reports link lavender products to breast growth in children, so keep them away from children.

learn PP405

Can PP405 help bald patches caused by stress? PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn procapil

Does pairing Procapil with antioxidants help stress-related hair thinning? No study has tested Procapil with antioxidants for stress-related shedding; evidence for Procapil itself is limited to the supplier's own tests and small combination studies.

learn Vitamin B5

Is Vitamin B5 beneficial for people experiencing stress-related or nutritional hair loss? Vitamin B5 is not proven to help with stress-related or nutritional hair loss.

learn Vitamin B6

Is Vitamin B6 helpful for stress-related or hormonal hair loss? Vitamin B6 may support overall health but lacks strong evidence for preventing hair loss.

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