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research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing

April 2019 in “Journal of Investigative Dermatology”

Activating the Sonic hedgehog pathway can help regenerate hair follicles during wound healing in mice, potentially improving regeneration after injury.

research Smoothened Antagonists for Hair Inhibition

7 citations, June 2010 in “Bioorganic & medicinal chemistry letters”

Two new compounds were found to effectively reduce hair growth in mice.

research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

271 citations, May 2019 in “Cells”

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

research Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient

9 citations, January 2017 in “Annals of Dermatology”

The study found genetic differences related to hair development that may explain hair loss in a patient with Trichorhinophalangeal syndrome type I.

research Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road

15 citations, October 2014 in “Journal of Investigative Dermatology”

New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

View more "smoothened pathway" in research →

Community Join

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community Why isnt topical fin talked about more?

in Chat 43 upvotes 1 week ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

community 5 months oralfin, topmin, dermarolling

in Progress Pictures 856 upvotes 1 year ago

The user "ninezske" shared their progress pictures of hair regrowth after using oral finasteride, topical minoxidil, and dermarolling. Other users commented on the results and discussed the effectiveness of minoxidil and finasteride.

community It's over. Hairline has fallen. Millions must shave.

in Update 467 upvotes 1 year ago

The conclusion of the conversation is that the user has tried various medications and treatments for hair loss, including minoxidil, finasteride, microneedling, and nizoral shampoo, but has not seen any progress. They have decided to shave their head. Other users suggest options such as hair transplants, RU58841, hair units, and scalp micropigmentation.

community Hairline Progress 24M - 4 month report. 5% min 1x/day, 1mg Fin every other day, 0.5mm microneedle 1x/week. Biotin and multivitamins too. Pretty stoked with the results!

in Progress Pictures 88 upvotes 2 years ago

A 24-year-old man shared his 4-month hair regrowth progress using 5% Minoxidil once daily, 1mg Finasteride every other day, weekly 0.5mm microneedling, Biotin, and multivitamins. Commenters suggest adding Tretinoin could enhance results, while others express happiness for his improvement.

community Ultimate DHT/finasteride microdosing graph to replace the commonly one referenced on forums

in Finasteride/Dutasteride 204 upvotes 3 years ago

Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHT levels, scalp skin and serum androgen levels, as well as hair count.