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Research

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Sweat Glands Shrink Upward With Aging, Causing Dermal Layer Defects Leading to Loss of Skin Elasticity and Wrinkling - Establishment of 3D Imaging Method for Skin Appendages

research 250 Sweat glands shrink upward with aging, causing dermal layer defects that lead to loss of skin elasticity and wrinkling-establishment of 3D imaging method for skin appendages

September 2017 in “Journal of Investigative Dermatology”

This study found that their novel 3D-imaging method, ASAXA-μCT, identified shrinkage of sweat glands as a key factor in skin aging, which leads to dermal defects, decreased elasticity, and increased wrinkling and sagging.

research Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women

24 citations , April 2017 in “Journal of Investigative Dermatology”

This study identified sex-specific determinants for facial wrinkles, finding that age is the strongest factor and that lifestyle influences like smoking, alcohol use, and skin color differentially affect wrinkling in men and women.

research The effects of infrared radiation on the human skin

July 2023 in “Photodermatology, Photoimmunology and Photomedicine”

This review compiles existing research on infrared radiation's effects on human skin, noting both its potential harmful thermal impacts and encouraging therapeutic applications, but reports no new clinical results.

research 211 Effect of 1α,25-dihydroxyvitamin D3 on mechanical properties of hairless mouse skin

June 1996 in “Journal of Dermatological Science”

Vitamin D3 applied to mouse skin caused more wrinkles and sagging due to changes in the skin's outer layer.

research The riddle of genuine skin microrelief and wrinkles

52 citations , November 2006 in “International Journal of Cosmetic Science”

This review discusses the identification and classification of different wrinkle types based on histological features and microanatomy, emphasizing their varying responses to treatments, and reports no new clinical results.

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Community Join

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community Did Dutasteride change how you look physically? your facial profile such as skin thickness, fat distribution or softness?

in Finasteride/Dutasteride 51 upvotes 1 year ago

Dutasteride and finasteride can cause changes in physical appearance, like more feminine features and increased water retention. Users report side effects such as reduced libido, weight gain, and improved skin clarity, while some notice no significant changes.

community Minoxidil and fine lines / ageing

4 upvotes 8 years ago

Minoxidil may cause fine lines and dark circles, but effects might be reversible with retinol. Users report mixed experiences, with some noticing skin changes and others not.

community The day they make a pill that only targets DHT production in the scalp

in Finasteride/Dutasteride 29 upvotes 1 year ago

Reducing DHT in the scalp is ideal for hair retention, with topical finasteride and dutasteride being common treatments. Some users report side effects like reduced libido, while others experiment with higher doses for regrowth.

community If minox causes facial wrinkles, then I should mix my Min/Fin for 1 dose daily, not 2?

4 upvotes 3 years ago

Minoxidil may cause facial aging, possibly due to alcohol and propylene glycol (PG) content. The user plans to reduce Minoxidil and Finasteride to one daily dose to minimize these effects.

community Minoxidil has been both a blessing and a curse

153 upvotes 2 months ago

Minoxidil can cause dark circles and aging appearance in some users, leading them to stop its use despite hair regrowth benefits. Some users suggest reducing dosage or switching to oral minoxidil to minimize side effects.

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Learn

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learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn retinol

How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.

learn Hyaluronic Acid

Does hyaluronic acid really hydrate the scalp, or is it mainly for skin care? Hyaluronic acid can hydrate the scalp, but its effectiveness may vary.

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Clinics

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Experts

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35
SMP Specialist
Noelle Skin
Nice, France

Noelle Skin