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Glossary Skin Transcriptome

complete set of RNA molecules produced in skin cells

The skin transcriptome refers to the complete set of RNA molecules, or transcripts, produced in the skin cells. This includes all the genes that are actively being expressed at any given time, providing insights into the skin's functions, responses to environmental factors, and conditions like alopecia. Understanding the skin transcriptome helps researchers and clinicians identify molecular pathways involved in skin health and disease.

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research Skin transcriptome analysis identifies the key genes underlying fur development in Chinese Tan sheep in the birth and Er-mao periods

12 citations , February 2022 in “Gene”

In this study, researchers found that the FOS gene may play a significant role in promoting hair follicle development in Tan sheep between birth and the Er-mao period.

research Skin transcriptomic and selection signature analyses identify ASIP as a key gene in cattle coat color determination

2 citations , April 2025 in “Frontiers in Genetics”

This study investigated the genetic basis of coat color variation in cattle using skin transcriptome and whole-genome analyses, identifying the ASIP gene as a significant determinant that is differentially expressed and under strong positive selection in black and brown cattle breeds.

research Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

2 citations , April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that skin surface lipids contain measurable mRNAs, providing a non-invasive way to study skin diseases, with specific gene expression changes observed in atopic dermatitis patients.

research Skin Transcriptome Analysis Identifies the Key Genes Underlying Fur Development in Chinese Tan Sheep in the Birth and Er-mao Periods

May 2020

This study found that the FOS gene may play a significant role in promoting hair follicle development in Tan sheep, with elevated expression during the Er-mao period.

Spatial Transcriptomic Analysis of Imiquimod-Treated Mouse Skin Reveals Deregulation of Lipid Raft-Associated Markers Reversible by Caveolin Scaffolding Domain Peptide

research 1619 Spatial transcriptomic analysis of imiquimod-treated mouse skin reveals deregulation of lipid raft-associated markers which could be reversed by re-introduction of caveolin scaffolding domain peptide

April 2023 in “Journal of Investigative Dermatology”

This study suggests that caveolin-1 may be a potential target for treating psoriasis, as its downregulation was linked to psoriasis markers that improved with soluble caveolin scaffolding domain peptide treatment.

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community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Bee venom better than minoxidil?

in Research/Science 1061 upvotes 9 months ago

Bee venom at 0.001% concentration was more effective than 2% minoxidil in promoting hair growth in mice, possibly due to increased growth factors and reduced inflammation. Caution is advised due to potential allergic reactions and the reliance on animal data.

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