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Glossary Pigmentation Changes

alterations in skin, hair, or eye color due to melanin variations

Pigmentation changes refer to alterations in the color of the skin, hair, or eyes due to variations in melanin production. These changes can manifest as hyperpigmentation (darkening) or hypopigmentation (lightening) and may result from factors such as sun exposure, hormonal changes, medical conditions, or certain medications. Understanding these changes is crucial for diagnosing and treating various dermatological conditions.

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Research

5 / 1000+ results

research Physiological changes in the skin during pregnancy

96 citations , January 1997 in “Clinics in Dermatology”

This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.

research Unraveling Dermatological Manifestations after COVID-19: Insights from Skin Pigmentation and Hair Loss Patterns

February 2025 in “The Open Dermatology Journal”

In this study conducted at Afzalipour Hospital in Iran, researchers found a significant prevalence of alopecia, particularly resembling telogen effluvium, among COVID-19-recovered patients, with hair loss being more common in females and correlating with arterial oxygen saturation levels.

research Senile Changes of Dog Skin

6 citations , January 1967 in “Journal of Small Animal Practice”

This study observed that aged dogs exhibit atrophy of the epidermis, appendages, and dermis, along with variable skin changes and increased dermal pigmentation, but lack senile elastosis seen in humans.

research 458 UVB-induced facultative pigmentation is associated with distinct DNA methylation changes

November 2025 in “Journal of Investigative Dermatology”

This study found that UVB exposure led to visible tanning and distinct DNA methylation changes in pigmentation genes in tan-capable skin but not in non-tan skin, highlighting GNAS as a potentially UVB-responsive gene.

research Microneedling-assisted Panax ginseng exosome protocol for vulvovaginal symptoms and vulvar skin tone changes: A preliminary pilot observational study

August 2026 in “Women s Health”

This preliminary pilot study found that a combined microneedling-assisted Panax ginseng exosome protocol with adjunctive inner gel use led to short-term improvements in patient-reported vulvovaginal symptoms and qualitative improvements in vulvar skin tone, though results are preliminary and based on a small, uncontrolled sample.

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Community Join

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community Just received my 2 Deoxy D Ribose wish me luck🫡

245 upvotes 2 years ago

A user is trying 2-deoxy-D-ribose with distilled water for hair growth, observing new hair and skin pigmentation changes. Others compare it to Minoxidil, expressing interest and caution about its effectiveness and safety.

community Rosemary Oil experiment 4 months in

in Research/Science 46 upvotes 5 months ago

A user experimented with applying pure rosemary oil to a single hair strand twice daily, observing increased thickness and pigmentation, but questioned if the oil or the application method caused the change. Some users noted rosemary oil might be as effective as 2% minoxidil for hair growth, though others warned about potential harm from using undiluted oil.

community John Cena Says Hair Transplant 'Changed The Course Of My Life' and maintains with daily routine that includes "red-light therapy, minoxidil, vitamins, shampoo"

in Transplants 2620 upvotes 1 year ago

John Cena attributes his improved life and career to a hair transplant and maintenance routine with red-light therapy, minoxidil, vitamins, and shampoo. Users discuss the effectiveness and side effects of finasteride, with mixed opinions on its necessity.

community White hair seemed to be turn black, re-pigmentation

1 upvotes 10 months ago

The user experienced hair repigmentation and attributes improvements in hair and overall health to a carnivore diet, Boron, and Selenium supplementation. They stopped using finasteride after 20 years, noticed increased testosterone and libido, and observed hair regrowth with RU58841.

community Why the Brain Resists Updating Your Appearance: The Neuroscience Behind “It Happened Overnight”

6 upvotes 7 months ago

The brain resists updating its perception of gradual appearance changes, like hair loss, due to its preference for stability and reliance on an internal model. This delay in perception can make changes feel sudden once the brain finally updates its model.

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Learn

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learn Scalp Micropigmentation

Is scalp micropigmentation a tattoo? Scalp micropigmentation is a specialized form of tattooing for hair loss.
Is scalp micropigmentation safe? Providers describe scalp micropigmentation as low-risk when a trained practitioner uses sterile single-use equipment, but that is a provider claim rather than a regulatory finding: pigment allergy, infection and colour change are documented risks of cosmetic tattooing.
Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
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Clinics

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Experts

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35
SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin