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research Skin metabolism in obesity: A narrative review

September 2024 in “Wound Repair and Regeneration”

This study explored the molecular factors behind delayed wound healing in obesity, highlighting that systemic changes like inflammation and collagen deposition alterations contribute to sustained skin inflammation and reduced mechanical resistance.

research Skin aging as a mechanical phenomenon: The main weak links

41 citations , May 2018 in “Nutrition and healthy aging”

This study suggests that age-related changes in skin elasticity reduce its stability against wrinkling, and anti-aging strategies should focus on addressing elastic mismatches between skin layers.

research General theory of skin reinforcement

18 citations , August 2017 in “PLOS ONE”

This study reports that the mechanical interactions between human skin and adjacent subcutaneous white adipose tissue influence the appearance of skin wrinkles, with sWAT reinforcement potentially more effective for reducing signs of skin aging than skin reinforcement alone.

research LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development

August 2019 in “Journal of Investigative Dermatology”

This study found that the desmosomal protein desmoplakin is crucial for proper epidermal morphogenesis and radial intercalation in developing Xenopus embryos, affecting keratin organization and ectodermal structures.

research Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride

23 citations , July 2021 in “International Journal of Pharmaceutics”

This study describes the development of microneedle array patches for finasteride that released the drug over 7 to 14 days in vitro, suggesting a potential alternative to oral treatments for long-term management of benign prostatic hyperplasia and androgenic alopecia.

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community Occipitalis Muscle Tension Theory

13 upvotes 7 months ago

Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Elon Musk just became the richest man in the world & i got a proposal he cant refuse.

276 upvotes 5 years ago

The conversation humorously suggests Elon Musk should focus on finding a cure for hair loss instead of space exploration, mentioning treatments like hair transplants, Minoxidil, and finasteride. It highlights the emotional impact of hair loss and the potential financial gain from a cure.

community Take the meds, but know that LIFESTYLE MATTERS

in Research/Science 20 upvotes 5 months ago

Minoxidil and finasteride aid hair regrowth, but a healthy lifestyle, including proper nutrition and maintaining a healthy weight, enhances their effectiveness. Being underweight can impede hair regrowth, while a balanced diet and addressing deficiencies can improve outcomes.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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Noelle Skin
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Noelle Skin