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Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With an Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations , June 2017 in “Journal of pharmaceutical sciences”

This study found that adapalene-loaded nanospheres in a hyaluronic acid gel enhanced skin penetration and were nonirritant, making them potentially suitable for treating acne on oily skin.

research Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery

15 citations , February 2014 in “Toxicology Letters”

This study found that osthole, a coumarin derivative, demonstrated significantly higher skin accumulation and potential skin irritation compared to coumarin, which showed negligible alterations in protein biomarkers.

research Panax notoginseng saponins loaded W/O microemulsion for alopecia therapy with panthenol as cosurfactant to reduce skin irritation

August 2024 in “International Journal of Pharmaceutics”

This study found that a specially designed water-in-oil microemulsion containing Panax notoginseng saponins improved hair density and other hair health indicators in mice with telogen effluvium and androgenetic alopecia, offering a promising multi-mechanism strategy for alopecia treatment with potentially fewer side effects than traditional methods.

research Ion pairs of risedronate for transdermal delivery and enhanced permeation rate on hairless mouse skin

34 citations , July 2011 in “International journal of pharmaceutics”

This study found that ion-paired solutions significantly improved the skin penetration of risedronate in hairless mice compared to risedronate alone.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, topical application of the SCD1 inhibitor XEN103 significantly reduced sebaceous gland size and number in mouse skin, suggesting potential local therapeutic effects for acne treatment without systemic side effects.

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Community Join

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community [26M] Min 5 month progress, worse skin?

49 upvotes 2 years ago

A user experienced skin irritation and acne while using Minoxidil foam, but after stopping both the foam and a sea salt spray, their skin improved. They plan to try oral Minoxidil, suspecting the sea salt spray, not Minoxidil, was the main cause of their skin issues.

community Adding Creatine while on fin + min has caused my skin to become red and terrible

3 years ago

Adding creatine while using finasteride and minoxidil caused skin irritation and hair thinning. Creatine may affect DHT levels, leading to these issues.

community PG causing irritation when applying RU

in Research/Science 3 years ago

The user is experiencing irritation from using PG with RU58841 and is seeking alternative solutions like K&B in the UK. They report redness, itchiness, and flaky skin from the current treatment.

community Minoxidil scalp irritation, is there any solution?

4 upvotes 6 years ago

The conversation is about managing scalp irritation caused by minoxidil use. Suggestions include switching to foam, using fluocinonide topical solution, trying lipogaine for sensitive skin, and considering low-dose oral minoxidil.

community how do you get tretinoin for hair? all I get is cream for the skin of the face

in Treatment 1 upvotes 1 year ago

Mixing tretinoin gel with Minoxidil for hair application is discussed, with suggestions to mix per application to avoid clogging and degradation. Some users apply tretinoin cream to the hairline and use Minoxidil and finasteride, noting potential irritation on the crown.

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Learn

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learn Niacinamide

Can Niacinamide help reduce scalp irritation or dandruff? Niacinamide may help reduce scalp irritation and dandruff by improving skin barrier function.

learn Fluocinolone

Is Fluocinolone a treatment for hair loss itself or just for calming scalp irritation? Fluocinolone acetonide is a prescription corticosteroid approved for inflammatory skin conditions, not for hair loss; no published human trial has measured hair regrowth with it, so at most it may help indirectly by calming an inflamed scalp.

learn Nanoxidil

Are there any side effects to watch out for when using Nanoxidil? Possible side effects of Nanoxidil include skin irritation and unwanted hair growth.

learn Rapamycin

Are there any visible side effects when using rapamycin cream or serum on the scalp? Visible side effects may include skin irritation or redness when using rapamycin on the scalp.

learn Tea tree

Are there limitations or considerations when using tea tree oil in hair loss or scalp treatment products? Tea tree oil can cause skin irritation and should be used cautiously on sensitive scalps.

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Epidermal Growth Factor

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn sh-Polypeptide-7

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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Clinics

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Experts

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35
SMP Specialist
Noelle Skin
Nice, France

Noelle Skin