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This study observed that during the postnatal development of gray short-tailed opossums, skin transitions from facilitating gas exchange through a dense capillary network at birth to supporting thermoregulation, with significant changes in skin thickness and structure occurring by 35 days old.

This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.

Hair removal methods damage the skin barrier and affect substance penetration.

The new skin organoid system effectively mimics human skin for studying its functions, injuries, and diseases.

This study demonstrates that keratinocyte cell lines derived from cultured hair follicles can fully differentiate in organotypic skin models, offering a minimally invasive alternative to obtaining keratinocytes for research.