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research A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis

March 2021 in “Cell stem cell”

This study found that actomyosin contractility in suprabasal keratinocytes influences the proliferation and differentiation of epidermal stem/progenitor cells by acting as a niche element in the skin.

research Faculty Opinions recommendation of Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding.

May 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Hair can regrow in adult mice's skin after injury, and this regrowth doesn't come from existing hair cells but from skin cells in the wound, with Wnt7a protein helping this process. This could help treat baldness and scarring.

research Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

June 2021

This study found that chronic UVR exposure in mice and humans leads to a permanent loss of papillary fibroblasts in the upper dermis, which is associated with changes in the extracellular matrix.

research Dermal-Epidermal Interactions--Follicle Derived Cell Populations in the Study of Hair-Growth Mechanisms.

28 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that cultured papilla cells can induce follicle formation and hair growth when combined with different epidermal and dermal cells, highlighting their powerful inductive properties and potential for dermatological applications.

research Epidermal keratinocyte stem cells: their maintenance and regulation

25 citations , December 1992 in “Seminars in cell biology”

This review discusses how epidermal Langerhan's cells and dermal cells may influence keratinocyte environments, potentially aiding in the formation of stem cell niches and cellular variety in the basal layer, without providing novel results.

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community (/r/science X-post): Stress may turn your hair grey. The appearance of grey hairs after periods of stress or skin damage could be the result of depletion of stem cells from the base of the hair follicle, according to a new study : science

4 upvotes 13 years ago

Stress can cause hair to turn grey due to stem cell depletion at the hair follicle base. Treatments discussed include Minoxidil, finasteride, and RU58841 for hair loss.

community UVA researchers discovered stem cells that plays a crucial role in hair growth - We are closer than ever to the cure!

281 upvotes 1 year ago

Researchers at the University of Virginia discovered a new group of stem cells in hair follicles that could potentially restore hair growth. The findings suggest that activating these stem cells might offer a new way to combat hair loss, though practical treatments are still years away.

community Why everyone should be using topical Dutasteride

45 upvotes 3 months ago

Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

community Why you can still look forward to PP405 and JXL-069

22 upvotes 2 months ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

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Learn

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learn Hair Transplant

What is a hair transplant? A hair transplant is a surgical procedure that relocates hair follicles to areas of thinning.

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Clinics

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Experts

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SMP Specialist
Noelle Skin
Nice, France

Noelle Skin