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    Glossary Signal Transducer and Activator of Transcription 5

    protein that transmits signals to influence gene expression

    Signal Transducer and Activator of Transcription 5 (STAT5) is a protein that plays a crucial role in transmitting signals from the cell surface to the nucleus, where it can influence gene expression. It is particularly important in processes like cell growth, differentiation, and immune function. In the context of hair biology, STAT5 can be involved in the regulation of hair follicle development and cycling.

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    1. Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A case control study Skin Pharmacology and Physiology · 2022
    2. Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways Proceedings of the National Academy of Sciences of the United States of America · 2000 · 73 citations
    3. The JAK/STAT signaling pathway: from bench to clinic Signal Transduction and Targeted Therapy · 2021 · 489 citations
    4. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    5. Janus kinase inhibitors for alopecia areata: a review of clinical data Frontiers in Immunology · 2025 · 4 citations
    6. Topical metformin as a novel therapy for alopecia areata due to its immunologic effects Medical Hypotheses · 2023
    7. Baricitinib-Induced Trichilemmal Cyst Reactivation in a Woman With Alopecia Areata Cutis · 2025
    8. 59 Scarring alopecia is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege 2023
    9. JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia EMBO Molecular Medicine · 2024 · 8 citations
    10. Leptin and the skin: a new frontier Experimental Dermatology · 2009 · 108 citations
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