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research WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

197 citations , June 2009 in “American journal of human genetics”

This study found that previously undescribed WNT10A mutations are a prominent cause of various forms of ectodermal dysplasia, including OODD and Schöpf-Schulz-Passarge syndrome, with gender-specific phenotypic effects noted.

research Features of hyperandrogenism in men

1 citations , May 2021 in “Problemy e̊ndokrinologii”

This study found that in men, elevated androgen levels can occur at any age, with older men potentially exhibiting increased total testosterone due to higher levels of SHBG, and younger men showing various clinical manifestations like acne and alopecia.

research Androgenetic alopecia in COVID-19: Compared to what?

6 citations , July 2020 in “Journal of The American Academy of Dermatology”

This analysis suggests that the reported association between androgenetic alopecia and severe COVID-19 may be overstated, as prevalence rates in patients match expected levels based on prior studies.

research WNT10A , dermatology and dentistry

30 citations , June 2021 in “British Journal of Dermatology”

This review discusses the association between WNT10A gene variants and various ectodermal disorders, highlighting their clinical relevance in dermatology and dentistry, but reports no new findings.

research COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine

58 citations , December 2020 in “Mayo Clinic Proceedings”

This paper discusses the variability in COVID-19 susceptibility and severity, emphasizing factors like biological differences and suggesting potential precision medicine approaches, but it reports no new clinical results.

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community Interesting new publication suggesting that MPB should be assessed as a early warning sign for type-2 diabetes.

15 upvotes 8 years ago

Male pattern baldness (MPB) may be an early warning sign for type 2 diabetes due to its association with insulin resistance. Treatments discussed include testosterone therapy and finasteride, which affects hormone levels related to hair loss and insulin sensitivity.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.