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Glossary Secondary Intention Healing

wound heals naturally from the bottom up without stitches

Secondary Intention Healing refers to the process by which a wound heals naturally without surgical closure. Instead of stitching the wound edges together, the wound is left open and heals from the bottom up, through the formation of granulation tissue, contraction, and epithelialization. This method is often used for large, infected, or non-approximable wounds and typically results in a larger scar compared to primary intention healing.

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Research

5 / 1000+ results

research Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient

7 citations , January 2018 in “Journal of Tissue Viability”

This case report describes an 80-year-old patient whose scalp wound healed by secondary intention, with unexpected hair regrowth observed at 180 days, suggesting hair neogenesis is possible even in older adults.

research Surgical excision of acne keloidalis nuchae with secondary intention healing

24 citations , October 2007 in “Clinical and experimental dermatology”

This case report describes two men with acne keloidalis nuchae who experienced successful outcomes with excision followed by secondary intention healing, resulting in good cosmetic results and minimal recurrence.

research Potential of the Nano-Encapsulation of Antioxidant Molecules in Wound Healing Applications: An Innovative Strategy to Enhance the Bio-Profile

6 citations , January 2025 in “Molecules”

This review highlights the challenges in developing nano-scale drug delivery systems for natural antioxidants in wound healing, pointing out issues like low solubility and skin permeability, and discusses potential solutions such as combining polymers and lipids to enhance delivery effectiveness.

research Beyond Comfortable: A Removable Antibacterial Electroconductive Cellulose Nonwoven Dressing for Accelerated Wound Healing

2 citations , December 2025 in “Nano Letters”

This study developed a tannin-modified cellulose-polypyrrole dressing that accelerates wound healing by enhancing granulation tissue, optimizing collagen, and stimulating angiogenesis, while providing antibacterial protection against S. aureus and E. coli.

research γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection

1 citations , September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that skin-resident and recruited γδ T cells play a crucial role in an early wound healing response following cutaneous vaccinia virus infection, rather than in controlling virus replication.

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Community Join

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community Could male-pattern baldness have a secondary photobiological function? The Solar Window Hypothesis

11 upvotes 3 weeks ago

Male-pattern baldness might increase UVB exposure on the scalp, potentially affecting vitamin D and skeletal health. The hypothesis is debated, with some seeing it as a minor benefit in specific contexts.

community Are Derma Rollers Actually Harmful in the Long Run?

in Microneedling 40 upvotes 1 year ago

Derma rollers may cause scarring alopecia, leading some to prefer dermastamps or dermapens for microneedling. Combining minoxidil with microneedling is effective, but proper technique and healing time are essential to prevent damage.

community I need your help - transplant after care

in Transplants 1 upvotes 1 year ago

The user is concerned about post-hair transplant care, specifically regarding the use of a bandana, minoxidil, and tretinoin. They are advised to consider finasteride and possibly adjust the minoxidil dosage.

community 2dDR experiment. Seems to be doing something.

11 upvotes 1 month ago

A user shared their experience using 2-deoxy-D-ribose (2dDR) for hair regrowth, noting early positive results without side effects, alongside their long-term use of minoxidil and finasteride. They mentioned 2dDR's potential effectiveness in boosting blood flow to hair follicles and its availability online.

community Oral 1mg Finesteride 2mg Minoxidil

485 upvotes 3 months ago

The user experienced significant hair regrowth using 1mg finasteride and 2mg minoxidil daily, along with Nizoral shampoo and rosemary oil. They are curious about further improving hair density and whether increasing the minoxidil dose would help.

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Learn

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learn Thymosin Beta 4

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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