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Research

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research Investigation of Some Amino Acid Analogues and Metabolites as Inhibitors of Wool and Hair Growth

5 citations , May 1983 in “Australian journal of biological sciences”

This study found that concurrent administration of cycloleucine with ethionine prevented the weakening of wool fibers in sheep, whereas reduced glutathione did not have the same effect.

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.

research Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition

42 citations , February 1996 in “Journal of Investigative Dermatology”

This study found that spermidine, a polyamine, plays an essential role in hair growth in sheep follicles, while spermine is not required for normal follicle function.

research Vitamin B12 Malabsorption: The Pathophysiological Impacts on Neurological and Hair Physiology

January 2025 in “The International Journal of Gastroenterology and Hepatology Diseases”

This study explored how vitamin B12 is essential for hair growth and nervous system health, highlighting that factors causing its malabsorption, like gastric issues and smoking, can lead to optic neuropathy and hair loss.

research Extracellular Vesicles in Alzheimer’s Disease: Dual Roles in Pathogenesis, Promising Avenues for Diagnosis and Therapy

January 2026 in “Pharmaceutics”

This review discusses the dual role of extracellular vesicles in Alzheimer's disease, highlighting their potential in both exacerbating and alleviating the condition, and emphasizes the need for advanced technologies to enhance diagnosis and treatment.

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Community Join

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community There's hope for us, boys! Don't despair!

205 upvotes 1 day ago

Some people find baldness attractive, and preferences vary. Treatments like Minoxidil and finasteride are mentioned, but personal acceptance and confidence are emphasized.

community That's quite funny if you as me

40 upvotes 6 days ago

Finasteride use and its potential side effects, including erectile dysfunction and post-finasteride syndrome (PFS), with discussions on lifestyle factors and the influence of anxiety. Some users argue that PFS is not well-documented, while others share personal experiences of adverse effects.

community What's the point of finasteride if dutasteride exists?

43 upvotes 1 week ago

Finasteride is effective for hair loss with fewer side effects and quicker clearance compared to dutasteride, which is more potent but has a longer half-life and potentially more side effects. Users suggest starting with finasteride and considering dutasteride only if more hair retention is needed and side effects are manageable.

community What's the proper way to use a derma stamp?

104 upvotes 2 weeks ago

A user is seeking advice on using a derma stamp for hair loss treatment, alongside minoxidil and finasteride. Recommendations include cleaning the scalp, using alcohol or hypochlorous acid for sterilization, starting with a needle length of 0.5mm, and stamping once a week.

community What's your unpopular opinion?

56 upvotes 3 weeks ago

Minoxidil is criticized for being inconvenient and ineffective compared to finasteride, with some users experiencing issues like flaking and greasy hair. Alternatives like adenosine are suggested, and the effectiveness of minoxidil can be improved with tretinoin and dietary changes.

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Learn

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learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

learn Glycerin

What’s the difference between vegetable glycerin and synthetic glycerin in hair products? Vegetable glycerin is plant-derived, while synthetic glycerin is petroleum-based, but both are chemically identical.

learn Hyaluronic Acid

What’s the difference between using hyaluronic acid as a serum on the scalp versus taking it as a supplement? A serum sits on the scalp surface. Oral hyaluronic acid has small trials on facial wrinkles, none on the scalp or hair.

learn Salicylic acid

What’s the difference between using salicylic acid for scalp exfoliation versus regular shampooing? Salicylic acid loosens dead skin cells in the scalp's outer layer, while regular shampoo mainly washes away surface oil and dirt.

learn Pyrithione Zinc

What’s the difference between pyrithione zinc and salicylic acid when treating scalp buildup? Pyrithione zinc is an antifungal that slows the yeast linked to dandruff, while salicylic acid loosens and sheds scale; both are permitted US over-the-counter dandruff ingredients. Zinc pyrithione has been banned in EU cosmetics since 2022 because it is classified as toxic for reproduction.

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