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community Is S5 plus cream an okay alternative to finasteride?

4 upvotes 9 years ago

The conversation discusses using S5 plus cream (Spironolactone, Alfatradiol, and Tempol) as an alternative to finasteride for hair loss, with concerns about its effectiveness and potential systemic absorption. The original poster already uses 5% minoxidil and is seeking alternatives due to fears of finasteride's side effects.

community Thickening up a spot on the crown with S5 cream

3 upvotes 7 years ago

A user discusses helping their brother with hair thinning on the crown by using a laser comb and considering adding S5 spironolactone cream to his regimen, alongside finasteride, which he has used for three years with good results. The conversation mentions that S5 cream is no longer available in the US.

community Switch from fin to dut and its worse

4 upvotes 1 year ago

Switching from finasteride to dutasteride can worsen hair loss for some men due to increased testosterone levels. Topical treatments like RU58841 and Pyrilutamide are suggested to counteract these effects, but individual responses vary.

community PP405 mechanism question - looking for discussion

7 upvotes 5 months ago

PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

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Research

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research Diagnostik und Therapie der kutanen Androgenisierung im klimakterischen Übergang sowie in der Peri- und Postmenopause: Hirsutismus und Alopezie

2 citations , January 2012 in “Journal für Kardiologie (Krause & Pachernegg GmbH)”

This review discusses therapeutic principles for managing hirsutism and androgenetic alopecia during the menopausal transition and peri-/postmenopause but reports no new clinical results.

research Understanding Polycystic Ovary Syndrome

January 2025 in “Directory of Open access Books (OAPEN Foundation)”

This book reviews the symptoms, diagnosis, and treatments for Polycystic Ovary Syndrome, providing a comprehensive exploration but reports no new clinical results.

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learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

How does spironolactone help reduce hair loss when used in topical or oral treatments? Studies report that spironolactone slows androgen-driven follicle miniaturisation by blocking androgen receptors, with most evidence in women and mostly alongside minoxidil; it is a prescription drug and its use for hair loss is off-label.
Can spironolactone be combined with other hair growth treatments for better results? Pooled data report better results when spironolactone is combined with minoxidil than with either alone, but the studies are small, short and mostly in women, and no best combination or dose has been established.
Is spironolactone better for hair regrowth as a pill or as a scalp solution? Oral spironolactone has the stronger published evidence for hair regrowth; topical versions cause fewer systemic side effects but have been studied far less, and no trial has compared the two head to head.
All 5 questions on Spironolactone →