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research Crosslinking structure of keratin. V. Number and type of crosslinks in microstructures of untreated and potassium cyanide treated human hair

11 citations , September 1996 in “Journal of applied polymer science”

In this study, treatment with aqueous KCN selectively converted disulfide bonds to monosulfide crosslinks in hair, leading to changes in microstructural properties and rubberlike elasticity under specific laboratory conditions.

research Green chemistry method for hair strengthening and setting using visible light-mediated protein crosslinking

4 citations , June 2022 in “Journal of cleaner production”

This study found that a new eco-friendly hair crosslinking method using visible light and non-toxic chemicals caused less damage and improved mechanical properties compared to traditional thioglycolic acid treatment.

research Let’s not split hairs

July 2023 in “Nature Reviews Chemistry”

A new method strengthens hair without using harmful chemicals.

research Enzymatic Crosslinking of Amino Acids Improves the Repair Effect of Keratin on Hair Fibre

May 2023 in “Polymers”

This study found that a bio-based repair solution containing hydrolysed wool keratin, serine, and transglutaminase improved the physical and chemical properties of damaged hair, increasing its strength, flexibility, and thermal stability while offering long-lasting protection against chemical damage.

research Double Network Physical Crosslinked Hydrogel for Healing Skin Wounds: New Formulation Based on Polysaccharides and Zn2+

August 2023 in “International Journal of Molecular Sciences”

In this study, researchers developed a new sodium alginate/chitosan/Zn2+ hydrogel that showed improved physical properties, antibacterial activity, and biocompatibility, and demonstrated enhanced wound healing and skin regeneration in an in vitro model.

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Community Join

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community Federal Grant Cuts have impacted PP405 related research

459 upvotes 1 year ago

Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community 3 and a half month progress pic

260 upvotes 1 year ago

The user shared a 3.5-month hair regrowth update using finasteride, 5% topical minoxidil, micro-needling, and keto shampoo, along with lifestyle changes like reducing stress and improving diet. They encourage others to stay committed to their regimen despite initial slow progress.

community The Health Benefits of Head Hair

in Research/Science 19 upvotes 11 months ago

Hair provides protection against head trauma, reduces skin cancer risk, helps remove heavy metals, and aids in wound healing. The conversation emphasizes the health benefits of maintaining head hair beyond cosmetic reasons.

community 4 months in (1.2mg fin, 3mg min, thick fix shampoo)

830 upvotes 1 year ago

Impressive hair regrowth was achieved in 4 months using 1.2mg finasteride, 3mg minoxidil, and Thick Fix shampoo. No side effects were reported, and the user encouraged others to try these treatments.

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Learn

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learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

learn Glycerin

What’s the difference between vegetable glycerin and synthetic glycerin in hair products? Vegetable glycerin is plant-derived, while synthetic glycerin is petroleum-based, but both are chemically identical.

learn Hyaluronic Acid

What’s the difference between using hyaluronic acid as a serum on the scalp versus taking it as a supplement? A serum sits on the scalp surface. Oral hyaluronic acid has small trials on facial wrinkles, none on the scalp or hair.

learn Salicylic acid

What’s the difference between using salicylic acid for scalp exfoliation versus regular shampooing? Salicylic acid loosens dead skin cells in the scalp's outer layer, while regular shampoo mainly washes away surface oil and dirt.

learn Pyrithione Zinc

What’s the difference between pyrithione zinc and salicylic acid when treating scalp buildup? Pyrithione zinc is an antifungal that slows the yeast linked to dandruff, while salicylic acid loosens and sheds scale; both are permitted US over-the-counter dandruff ingredients. Zinc pyrithione has been banned in EU cosmetics since 2022 because it is classified as toxic for reproduction.

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