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Research

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research Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver

59 citations , May 2017 in “Scientific reports”

This study found that ZDHHC13 deficiency in mice is associated with abnormal liver function, lipid metabolism issues, and impaired mitochondrial function, highlighting ZDHHC13's regulatory role in liver metabolism.

research Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient

37 citations , September 2002 in “Acta pædiatrica”

In this study, a patient with cystic fibrosis developed iatrogenic Cushing's syndrome due to impaired clearance of budesonide from concurrent itraconazole use, highlighting the need for regular monitoring in such combination therapies.

research Characteristic features of ageing in Korean women’s hair and scalp

31 citations , December 2012 in “British Journal of Dermatology”

This study found that as Korean women age, their hair density, diameter, tensile strength, and lustre decline, while grey hair ratio and certain sterol contents increase, suggesting unique ageing features compared to women in other countries.

International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women

research International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women

30 citations , April 2021 in “The Journal of Sexual Medicine”

This guideline provides recommendations for prescribing systemic testosterone to women with hypoactive sexual desire disorder, emphasizing safe dosing, monitoring, and the need for informed consent despite regulatory challenges.

research The Implication of Neuroactive Steroids in Tourette's Syndrome Pathogenesis: A Role for 5α‐Reductase?

24 citations , June 2013 in “Journal of neuroendocrinology”

This research observed that 5α-reductase inhibitors showed significant tic-suppressing effects in Tourette's syndrome, suggesting a key role for this enzyme in the disorder's pathogenesis.

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Community Join

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community What's the proper way to use a derma stamp?

104 upvotes 6 days ago

A user is seeking advice on using a derma stamp for hair loss treatment, alongside minoxidil and finasteride. Recommendations include cleaning the scalp, using alcohol or hypochlorous acid for sterilization, starting with a needle length of 0.5mm, and stamping once a week.

community What's your unpopular opinion?

56 upvotes 1 week ago

Minoxidil is criticized for being inconvenient and ineffective compared to finasteride, with some users experiencing issues like flaking and greasy hair. Alternatives like adenosine are suggested, and the effectiveness of minoxidil can be improved with tretinoin and dietary changes.

community Let’s be real, does infrequent smoking really accelerate MPB and/or cause health issues?

10 upvotes 1 week ago

Smoking infrequently is unlikely to significantly impact hair loss or health, especially when using treatments like finasteride and minoxidil. Genetics play a larger role in hair loss, and low smoking frequency is not considered a major risk.

community How’s my progress? 2 months in - 2.5 mg min, 1 mg fin

21 upvotes 2 weeks ago

The user resumed 2.5 mg oral minoxidil and added 1 mg finasteride, Nizoral 2%, Vitamin D3+K2, and Biotin after noticing hair loss. They are seeing progress and are encouraged by the results after two months.

community Why aren't they researching how to make Minoxidil's effect permanent instead of it weaning off over time?

52 upvotes 4 weeks ago

Minoxidil's effects on hair regrowth diminish over time because it doesn't address the root cause of hair loss, and its mechanism isn't fully understood. Combining it with treatments like finasteride or dutasteride can help maintain its effectiveness, but permanent solutions are unlikely due to the complexity of hair loss biology.

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Learn

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learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

learn Glycerin

What’s the difference between vegetable glycerin and synthetic glycerin in hair products? Vegetable glycerin is plant-derived, while synthetic glycerin is petroleum-based, but both are chemically identical.

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn methylsulfonylmethane

learn Dimethiconol

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