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Retinoid X Receptor

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Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research In Situ Detection of Retinoid-X Receptor Expression in Normal and Psoriatic Human Skin

42 citations , August 1995 in “British journal of dermatology/British journal of dermatology, Supplement”

RXR-alpha is strongly expressed in both normal and psoriatic skin and may help in skin cell differentiation and hair growth.

research Physiological and Retinoid-Induced Proliferations of Epidermis Basal Keratinocytes Are Differently Controlled

127 citations , July 2002 in “EMBO journal”

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

research Analysis of 1,25-Dihydroxyvitamin D3 Receptors in Basal Cell Carcinomas

42 citations , August 1999 in “The American journal of pathology”

Basal cell carcinomas have much higher levels of Vitamin D3 receptors compared to healthy skin.

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

28 citations , January 2012 in “Biological & pharmaceutical bulletin”

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 3 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 443 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.