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research Protocol for preparing mammalian skin samples encompassing hair follicles for spatial transcriptomics

August 2024 in “STAR Protocols”

This study details a step-by-step protocol for preparing mammalian skin samples, including hair follicles, for spatial transcriptomics to overcome challenges inherent in applying this technique to the skin.

research Comprehensive single-cell transcriptomic profiling of the scalp from patients with moderate-to-severe alopecia areata

February 2026 in “Journal of Allergy and Clinical Immunology”

In this single-cell transcriptomic study, researchers analyzed AA scalp samples and found distinct immune and nonimmune cell activation patterns, with elevated TH1/TH2 and JAK/STAT markers potentially contributing to hair follicle immune privilege disruption and disease severity.

research Tracing Recombinant Bovine Somatotropin Ab(Use) Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells: A Matrix Comparison

4 citations , July 2018 in “Molecules”

This study found that blood and milk somatic cells show promise as matrices for monitoring illicit recombinant bovine somatotropin use in dairy cattle through gene-expression assays.

research Gut Microbiota-Derived Exosomes Are Unique Natural Nanocarriers for Therapeutics

January 2026 in “Biocell”

This review discusses the potential of gut microbiota-derived exosomes as drug delivery systems and reports no new clinical results; the authors highlight their promise for precision medicine.

research Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies

77 citations , August 2025 in “Signal Transduction and Targeted Therapy”

This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.

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Community Join

5 / 26 results

community Exosomes - do they work as results look promising?

2 upvotes 6 years ago

Exosomes are being considered for hair regrowth, with some users reporting initial improvement. One user moved on to using dutasteride and oral minoxidil with positive results.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Kintor stealing pictures from a hair transplant clinic to promote their failed product (KX826, Pyrilutamide)

in Product 314 upvotes 2 years ago

Kintor is accused of using fake pictures to promote their product, Pyrilutamide (KX826), which failed Phase 3 trials. Users express disappointment and note similar false advertising has occurred with finasteride and minoxidil.

community We need to keep these snake oil companies accountable.

in Treatment 120 upvotes 2 years ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 2 years ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

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