May 2025 in “Acta Biomaterialia” The new microneedle treatment effectively promotes hair growth better than minoxidil.
The study explores the effects of recombinant human type XVII collagen (rhCOL17A1) on hair growth, highlighting its potential as a safer hair restoration treatment. By activating the Wnt/β-catenin and SHH/GLI signaling pathways, rhCOL17A1 enhances the resistance of hair follicle dermal papilla cells to apoptosis and promotes hair regrowth. The research, conducted on 50 male C57BL/6 mice, demonstrated that rhCOL17A1 increases the expression of growth factors such as VEGF, IGF-1, and FGF-7, facilitating the transition of hair follicles from the telogen to anagen phase. These findings suggest that rhCOL17A1 could be a promising therapeutic agent for hair loss, with potential applications in hair care products to support long-term follicular health. Further studies are needed to evaluate its safety and optimal usage.
May 2025 in “International Journal of Biological Macromolecules” A new microneedle treatment shows promise for better hair regrowth in androgenetic alopecia.