research Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia
The new microneedle treatment effectively promotes hair growth better than minoxidil.
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3 / 3 resultsresearch Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways
The study explores the effects of recombinant human type XVII collagen (rhCOL17A1) on hair growth, highlighting its potential as a safer hair restoration treatment. By activating the Wnt/β-catenin and SHH/GLI signaling pathways, rhCOL17A1 enhances the resistance of hair follicle dermal papilla cells to apoptosis and promotes hair regrowth. The research, conducted on 50 male C57BL/6 mice, demonstrated that rhCOL17A1 increases the expression of growth factors such as VEGF, IGF-1, and FGF-7, facilitating the transition of hair follicles from the telogen to anagen phase. These findings suggest that rhCOL17A1 could be a promising therapeutic agent for hair loss, with potential applications in hair care products to support long-term follicular health. Further studies are needed to evaluate its safety and optimal usage.
research Borate-Modified Recombinant Type XVII Collagen Microneedles Loaded with IGF-1 for the Treatment of Androgenetic Alopecia
A new microneedle treatment shows promise for better hair regrowth in androgenetic alopecia.
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