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research Treatment of severe alopecia areata with intralesional steroid injections.

60 citations , October 2009 in “PubMed”

This study reports that intralesional triamcinolone acetonide was effective and well-tolerated for treating extensive alopecia areata in patients who often showed specific initial hair characteristics.

research Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis

5 citations , August 2015 in “Sultan Qaboos University medical journal”

This case report highlights an atypical presentation of vitamin B12 deficiency in a 28-year-old man with reversible symptoms including localized hand hyperpigmentation and megaloblastic anemia, resolved after B12 supplementation.

research TNF‐inhibitor associated psoriatic alopecia: Diagnostic utility of sebaceous lobule atrophy

20 citations , March 2017 in “Journal of cutaneous pathology”

This study describes tumor necrosis factor inhibitor-associated psoriatic alopecia, highlighting the distinctive histologic feature of sebaceous lobule atrophy, which is potentially reversible and helps differentiate it from idiopathic psoriatic alopecia.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, topical application of the SCD1 inhibitor XEN103 significantly reduced sebaceous gland size and number in mouse skin, suggesting potential local therapeutic effects for acne treatment without systemic side effects.

Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

research Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

6 citations , August 2014 in “Toxicologic pathology”

This study found that prolonged inhibition of DGAT1 in mice and dogs led to atrophy of sebaceous glands, with mice also experiencing alopecia, suggesting potential skin-related risks for humans using DGAT1 inhibitors.

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community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 5 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community If you were on finasteride, but experiencing negative symptoms and didn’t know about PFS, would you want someone to tell you?

in Finasteride/Dutasteride 5 months ago

Finasteride users discuss potential side effects, including Post Finasteride Syndrome (PFS), with varying opinions on its legitimacy and impact. Some users report side effects like changes in semen consistency and reduced pre-ejaculate, while others emphasize the rarity and reversibility of side effects.

community 8 months on oral minoxidil. No sign of regrowth.

in Minoxidil 14 upvotes 1 year ago

The user has been taking 2mg oral minoxidil and 1mg finasteride but has seen no hair regrowth after 8 months, leading to concerns about being a non-responder. They are considering increasing the minoxidil dosage or switching to dutasteride, while also using keto shampoo and microneedling, but remain skeptical about the effectiveness of minoxidil.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

23 upvotes 5 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

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