101 citations
,
November 2019 in “The Plant Cell” This study found that the zinc finger protein AtZP1 inhibits root hair initiation and elongation in Arabidopsis by suppressing key transcription factors involved in root hair development.
This research developed a zinc-doped nanocomposite using biodegradable materials, observing effective bone targeting and regeneration capabilities in vivo, with no observed cytotoxicity in the MG63 cell line, potentially due to blocking Farnesyl Diphosphate Synthetase to inhibit osteoclastic activity and promote osteogenesis.
25 citations
,
September 2005 in “Journal of Investigative Dermatology Symposium Proceedings” Adding zinc to pyrithione zinc improves its effectiveness against scalp conditions like dandruff.
4 citations
,
August 2011 in “Journal of Food Biochemistry” This study reports that α-casein in bovine milk can form stable complexes with zinc, potentially useful for fortifying milk-based products to enhance zinc availability.
22 citations
,
September 2024 in “Chemical Engineering Journal” A new microneedle patch effectively and safely treats alopecia areata.
6 citations
,
August 2021 in “International Journal of Cosmetic Science” This study concluded that a regimen containing functional antioxidants and barrier-enhancing agents reduced hair shedding and increased perceived hair fullness in participants with self-perceived hair thinning over 24 weeks.
52 citations
,
July 2011 in “PubMed” This review discusses the diverse roles of the TRPS1 gene in regulating cartilage, kidney, and hair follicle development, highlighting its functions and interactions, but provides no new experimental results.
1 citations
,
May 2016 in “Marmara Pharmaceutical Journal” This study determined the stability constants of finasteride complexes with cobalt, zinc, cadmium, and copper, which may inform analyses of blood samples.
1 citations
,
February 1993 in “Nursing Standard” This article highlights that nurses may not be sufficiently aware of the potential for various drug groups, beyond cytotoxic drugs, to cause alopecia, and emphasizes the importance of early recognition of this side effect.
June 2025 in “Journal of Cluster Science” This review explores the potential of metal nanoparticles as innovative treatments for alopecia, highlighting their effectiveness in promoting hair regrowth, enhancing drug delivery, and modulating gene expression while also assessing the related experimental methodologies and regulatory considerations.
104 citations
,
January 2022 in “Materials Today Bio” This study explored the development of zinc-incorporated gelatin-based hydrogels, which demonstrated strong antibacterial properties and supported skin cell health, ultimately improving the healing process of S. aureus-infected full-thickness wounds, showing promise as wound dressings for infected wounds.
January 2025 in “Cell Communication and Signaling” This study reviews the role of the zinc finger protein CXXC5 in cellular signaling and its implications for cancer, discussing how its dysregulation is linked to various physiological and pathological processes, as well as potential therapies targeting CXXC5.
9 citations
,
September 2018 in “Clinical, Cosmetic and Investigational Dermatology” This study found that, in female patients with idiopathic telogen effluvium, a supplement containing zinc, biotin, and other nutrients significantly improved hair loss and quality over 180 days, whereas another supplement with different ingredients had less consistent effects.
In this study, a pH-responsive microneedle patch was developed, showing potential in rat models for treating spinal cord injuries by reducing inflammation, promoting nerve regeneration, and supporting neurogenesis, which contributed to improved motor and neurological recovery.
10 citations
,
January 2016 in “Global Dermatology” This study observed that zinc deficiency in humans and mice was associated with diminished allergic contact dermatitis but increased severity and duration of irritant contact dermatitis.
14 citations
,
August 2016 in “Journal of nanomedicine research” This animal study found that biscuits fortified with zinc oxide nanoparticles improved growth, appetite, and hair growth in zinc-deficient rats more effectively than traditional zinc forms, without apparent toxicity.
19 citations
,
July 2020 in “Journal of drug delivery science and technology” This study found that nano-sized minoxidil formulations significantly increased skin penetration and follicular drug delivery for alopecia areata treatment, compared to conventional ethanol-based solutions, and demonstrated effective controlled release over six hours.
73 citations
,
May 1976 in “JAMA” This case report associates severe zinc deficiency with long-term total parenteral nutrition, suggesting the need for trace element supplementation in such nutritional management.
19 citations
,
February 2018 in “Nutrients” This review discusses the relationship between zinc deficiency and skin disorders, emphasizing zinc transporters' roles, but it reports no new clinical results; the authors highlight potential benefits of regulating zinc levels via transporters.
165 citations
,
January 2014 in “Dermatology Research and Practice” This review discusses the various dermatological applications of zinc, including its use in treating infections, inflammatory dermatoses, pigmentary disorders, and neoplasias, and reports no new clinical findings.
35 citations
,
January 2006 in “Journal of Dermatological Treatment” This review found little evidence supporting zinc as a first-line treatment for dermatological conditions, except in cases of systemic zinc deficiency, and suggests further research is needed.
27 citations
,
May 2010 in “Dermatologic Clinics” This review discusses the use of zinc in treating dermatological conditions and concludes that, aside from systemic zinc deficiency, its efficacy as a primary treatment is unproven, though it may be useful as a supplementary therapy.
August 2024 in “Turkish Journal of Pediatric Disease” This case report details a 5-month-old infant with acrodermatitis enteropathica, linked to zinc deficiency from total parenteral nutrition, who showed improvement using zinc spray and cream, contrasting with typical literature outcomes.
264 citations
,
January 2008 in “Journal of biomedical optics” This study found that ZnO nanoparticles in topical skin products do not penetrate beyond the outer skin layers in humans, suggesting minimal safety concerns for subdermal absorption.
9 citations
,
April 2023 in “Journal for Research in Applied Sciences and Biotechnology” This narrative discusses the critical roles of zinc in both biological processes and industrial applications but provides no new research findings.
7 citations
,
January 2007 in “Elsevier eBooks” This article reviews the composition and functionality of shampoos, emphasizing the role of surfactants in cleaning and conditioning hair, and reports no new experimental results.
2 citations
,
July 2013 in “EDIS” This fact sheet discusses the impacts of zinc deficiency, including its effects on the immune system, cognitive function, and growth in children, and highlights the increased risk for those who consume alcohol excessively; it reports no new clinical results.
November 2025 in “Frontiers in Veterinary Science” In this study, zinc supplementation at 2.00 g/camel/day improved hair growth in lactating camels but did not affect milk production, while for calves, doses of 0.50–0.75 g/camel/day enhanced growth and hair development.
January 2021 in “Middle East journal of applied sciences” This article discusses the widespread issue of zinc deficiency affecting plant, animal, and human health, and reports no new clinical results; the authors emphasize the need for adequate zinc availability in agriculture and nutrition.
46 citations
,
May 2020 in “Cureus” This review analyzes the molecular and genetic roles of zinc, its connection to diarrheal disease, dietary recommendations, and the impacts of zinc deficiency on health, but reports no new data.