April 2016 in “Chinese Journal of Dermatology” This study found that Wnt10b induces hair follicle regeneration in mice, likely by activating the canonical Wnt signaling pathway in stem cells and their daughter cells.
This study found that the Wnt10b gene promotes, while the SFRP2 gene inhibits, hair growth in Wanxi Angora rabbits, influencing the hair growth cycle and follicle regeneration.
September 2017 in “Journal of Investigative Dermatology” This study found that in AGA, the risk allele at locus 2q35 alters WNT10A expression through EBF1, suggesting a potential androgen-dependent regulatory mechanism.
248 citations
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November 2011 in “The EMBO Journal” This study found that Wnt1/βcatenin signaling plays a crucial role in activating the epicardium and cardiac fibroblasts, which supports cardiac repair following acute ischemic injury.
25 citations
,
August 2017 in “Animal Biotechnology” This study identified and characterized several long noncoding RNAs in Cashmere goats, revealing complex regulatory roles in hair follicle development and growth, particularly within the Wnt signaling pathway.
22 citations
,
October 2012 in “Cell Transplantation” This study found that adding Wnt-10b to the culture medium of dermal papilla cells maintained their ability to induce hair follicles over 100 days in vitro.
11 citations
,
January 2015 in “PubMed” This study found that the 2,940 nm erbium: YAG laser may promote hair growth in C57BL/6 mice by speeding up transitions in the hair cycle and increasing hair follicle numbers.
1 citations
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November 2020 This study found that a pro-fibrotic Wnt1/βcatenin injury response is crucial for maintaining cardiac function following acute ischaemic cardiac injury by activating the epicardium and cardiac fibroblasts.
October 2019 in “Journal of Pakistan Association of Dermatologists” In this study, NB-UVB therapy significantly increased Wnt1 and β-catenin expression in hair follicles, which may play a role in vitiligo perifollicular repigmentation.
89 citations
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September 2010 in “Annual Review of Genomics and Human Genetics” This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.
74 citations
,
January 2013 in “Journal of Investigative Dermatology” Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.
53 citations
,
April 2014 in “Experimental Dermatology” In this study, ectopic Wnt10b-mediated β-catenin activation in hair follicles resulted in larger regenerating anagen hair structures, an effect modulated by the Wnt inhibitor DKK1.
49 citations
,
February 2008 in “Stem Cells” This study found that after injury, the bone marrow microenvironment's increased Wnt10b expression supports hematopoietic stem cell regeneration by enhancing Wnt signaling, revealing a vital interaction during recovery.
47 citations
,
October 2016 in “Molecular and Cellular Endocrinology” This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.
46 citations
,
August 2012 in “Experimental Dermatology” In this study, engineered skin substitutes containing murine dermal papilla cells developed hair follicle-like structures when grafted onto mice, suggesting a model for generating chimeric hair.
45 citations
,
April 2016 in “Journal of Dermatological Science” This study found that the Wnt/β-catenin signaling pathway activates melanocyte stem cells, promoting hair follicle regeneration both in vitro and in vivo.
43 citations
,
November 2018 in “Nature Communications” This genome-wide association study identified 20 genetic signals at 15 risk loci related to severe acne, revealing new insights into its genetic predisposition, particularly affecting skin structure and maintenance.
36 citations
,
September 2015 in “Forensic Science International: Genetics” This study found that specific DNA variants in the TCHH, WNT10A, and FRAS1 genes are associated with predicting straight hair in Europeans, showing high sensitivity but low specificity, especially using a neural networks approach.
32 citations
,
June 2015 in “PLOS ONE” This study demonstrated that topical oleuropein induced hair growth in mice by activating the Wnt10b/β-catenin signaling pathway and increasing expression of several growth-related genes in skin tissue.
32 citations
,
July 2012 in “Stem Cells Translational Medicine” In this study, VD(3) pretreatment increased hair follicle formation in a rat model by promoting dermal papilla cell differentiation, suggesting potential for hair regeneration therapy.
30 citations
,
June 2021 in “British Journal of Dermatology” This review discusses the association between WNT10A gene variants and various ectodermal disorders, highlighting their clinical relevance in dermatology and dentistry, but reports no new findings.
28 citations
,
February 2010 in “British journal of dermatology/British journal of dermatology, Supplement” This article reviews phenotypic variability linked to WNT10A nonsense mutations and does not present new research findings.
25 citations
,
April 2015 in “Journal of Investigative Dermatology” This study found that Gsdma3 mutation in mice allows hair follicles to bypass a typical telogen phase and directly enter the anagen phase, suggesting Gsdma3's role in hair cycle transitions by regulating Wnt signaling.
20 citations
,
April 2016 in “Journal of Cosmetic Dermatology” In this study, topical methyl vanillate application increased hair count and hair mass index in women with androgenetic alopecia by enhancing WNT10B expression, suggesting a potential new treatment strategy.
19 citations
,
April 2020 in “Journal of ethnopharmacology” This study found that nut oil from Prunus mira promoted hair growth in mice, potentially through the Wnt/β-catenin signaling pathway.
19 citations
,
January 2015 in “Development” This study found that misexpression of Hoxc8 in mice led to ectopic mammary development and suggests Hox genes may play crucial roles in the regional specification and initiation of cutaneous accessory organs.
19 citations
,
January 2014 in “International Journal of Medical Sciences” The study suggests that abnormal activation of hair follicle stem cells and Wnt10b/β-catenin signaling may contribute to the development of sebaceous neoplasms.
18 citations
,
July 2016 in “Medicine” This study suggests that crosstalk between Wnt/β-catenin and TGF-β signaling pathways may contribute to the development of androgenetic alopecia.
16 citations
,
December 2020 in “PloS one” In this study, WNT10A was identified as a key gene in the development and maturation of skin hair follicles in fetal Inner Mongolian cashmere goats.
14 citations
,
June 2022 in “BMC genomics” This study identified key genes involved in hair follicle development in Merino sheep, offering insights for improving wool production and providing a basis for future breeding programs.