20 citations
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September 2019 in “Journal of Cosmetic Dermatology” This study found that combining stromal vascular fraction with PRP injections significantly improved hair density and reduced hair loss more effectively than PRP alone in patients with androgenetic alopecia.
20 citations
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July 2019 in “Stem cell investigation” This study found that the combination of stromal vascular fraction and platelet-rich plasma accelerated wound healing in rats more effectively than either treatment alone or saline.
19 citations
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April 2021 in “Stem Cell Research & Therapy” This study found that transplantation of autologous stromal vascular fraction cells increased skin thickness and improved regeneration when combined with mechanical stretching, without severe adverse events.
16 citations
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April 2016 in “PLoS ONE” In a porcine model, this study observed that using an External Tissue Expansion Device increased epidermis thickness, cell proliferation, and vessel density at fat graft recipient sites.
13 citations
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June 2020 in “Stem Cells International” In this study using a mouse model, ECM/SVF-CM, derived from adipose-derived stem cells, was observed to stimulate hair growth more effectively than SVF-CM by promoting cell proliferation, neovascularization, and anagen induction, which may support its potential as an improved treatment for hair loss.
13 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” This review discusses the potential effectiveness of cell therapy for hair loss, highlighting promising early findings but emphasizing that more research is needed to explore specific therapies like autologous fat grafting and mesenchymal stem cells.
11 citations
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August 2023 in “Regenerative Therapy” This study proposes a reporting guideline, CLINIC - STRA-SVF, to standardize and improve the design and reporting of clinical studies involving SVF, highlighting its safety and effectiveness despite the low level of current evidence.
11 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” This study reviewed the prospects and challenges of using stem cells from adipose tissue in regenerative medicine for facial rejuvenation, emphasizing the need for further research to ensure patient safety before these methods can become routine in cosmetic and reconstructive surgery.
11 citations
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June 2018 in “Sexual medicine reviews” This review evaluates existing preclinical and clinical studies on stromal vascular fraction for treating male sexual dysfunction, finding limited data and emphasizing the need for more research before conducting clinical trials.
7 citations
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June 2024 in “Skin Research and Technology” Combining treatments significantly reduces dark circles and wrinkles better than nanofat alone.
7 citations
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June 2020 in “Translational Andrology and Urology” This study evaluated potential penile vascular changes and persistent adverse effects in men discontinuing 5α-reductase inhibitors for androgenic alopecia, but no new clinical results were reported.
3 citations
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December 2020 in “Journal of the turkish academy of dermatology” This study concluded that stromal vascular fraction treatment was effective in increasing hair density and thickness in patients with androgenetic alopecia over a three-month period.
1 citations
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December 2023 in “PubMed” This study on rats found that combining platelet-rich plasma with stromal vascular fraction cells helped accelerate burn wound healing by affecting inflammatory cell counts and COX-2 expression, with differing impacts observed between acute and sub-acute phases of healing.
1 citations
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December 2022 in “Archives of Dermatological Research” This study reported significant improvements in hair density, diameter, and patient satisfaction after using non-enzymatic stromal vascular fraction treatment for androgenic alopecia over six months.
1 citations
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December 1996 in “Cell Biology and Toxicology” June 2026 in “Indian Dermatology Online Journal” This study in North India found that patients with alopecia areata have significantly higher levels of coagulation markers, metabolic dysregulation, and systemic inflammation compared to healthy controls, and these factors are linked with disease severity, indicating potential systemic implications beyond localized hair loss.
April 2026 in “Stem Cell Research & Therapy” This systematic review reports that regenerative medicine therapies, such as conditioned media, platelet-rich fibrin, and stem cells, show promising efficacy and safety in treating androgenetic alopecia, though heterogeneity in study protocols and limited long-term data emphasize the need for further research to optimize these strategies.
January 2025 in “Journal of Carcinogenesis” This study concluded that stromal vascular fraction and topical minoxidil both improved hair characteristics in male and female patients with androgenetic alopecia, but SVF offered a more satisfactory treatment experience.
This review of SVF treatment for androgenetic alopecia found a significant increase in hair density across studies with no serious adverse events, but calls for standardized protocols and further research.
April 2023 in “Research Square (Research Square)” The researchers reported that combining stromal vascular fraction (SVF) with fractional CO2 laser treatment significantly improved burn scar outcomes and patient satisfaction compared to using the laser alone.
July 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this patient series, researchers observed that subcutaneous scalp injections of adipose tissue enriched with stem cells showed potential as a safe and promising treatment for early genetic hair loss in men and women, based on photographic and quantitative assessments.
July 1996 in “Annals of Internal Medicine” This letter discusses the importance of microvascular disease in renal arterioles as a common cause of renal failure progressing to end-stage renal disease, a topic often overlooked in nephrology literature.
March 2022 in “Al-Azhar International Medical Journal (Print)” In this study, among individuals with androgenic alopecia, stromal vascular fraction injections led to greater clinical improvement and hair density increases compared to nanofat injections, with 26.7% of participants showing great improvement versus 6.7% in the nanofat group after six months.
October 2021 in “Journal of Investigative Dermatology” In this study, the researchers found that scalp hair follicles affected by female pattern hair loss are poorly vascularized, likely affecting nutrient delivery, but capable of nutrient uptake when supplemented.
March 2021 in “Postepy Dermatologii I Alergologii” In this study, topical 5% minoxidil significantly increased total hair count in women with female pattern hair loss after 6 months, and scalp vascularization did not affect treatment efficacy.
March 2020 in “QJM: An International Journal of Medicine” In this study, significant improvements in Androgenetic Alopecia were observed with both PRP and SVF therapies, with SVF showing greater effectiveness in increasing terminal and vellus hair counts.
124 citations
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November 2019 in “International Journal of Molecular Sciences” This review discusses different processing methods for isolating human AD-SVFs/AD-MSCs using various kits and reports no new clinical results, highlighting the need for standardized preparation techniques.
17 citations
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May 2021 in “Journal of Applied Pharmaceutical Science” This review highlights that transferosomes, or ultradeformable lipids, show promise for improving dermal delivery, exhibiting efficient drug transport across the skin's barrier and offering potential benefits for treating chronic skin disorders with better bioavailability.
14 citations
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November 2018 in “Journal of drug delivery and therapeutics” This article reviewed the preparation, application, and characterization of ethosomes as drug delivery transporters and reported that in a double-blind randomized clinical study, ethosomal acyclovir significantly improved all evaluated parameters in skin delivery, highlighting potential for novel therapies.
January 2025 in “AAPS PharmSciTech” Transethosomes improve drug delivery through the skin and show promise for treating various conditions.