July 2026 in “Functional Foods in Health and Disease” In this study, oral administration of strawberry guava extract promoted hair growth in both mice and humans, with active components like adenosine, fructose, digalactosyldiacylglycerol, and pedunculagin contributing by enhancing skin blood flow and activating dermal papilla cells.
34 citations
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July 2018 in “American Journal of Physiology-heart and Circulatory Physiology” Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.
60 citations
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February 2015 in “Biomaterials” In this study, immobilized VEGF selectively captured endothelial cells under various shear stresses, suggesting its potential for promoting endothelialization in vascular grafts or implanted tissues.
8 citations
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May 2017 in “Chinese Journal of Integrative Medicine” Among in vitro and in vivo models, this study found that Miscanthus sinensis var. purpurascens flower extract may promote hair growth, potentially by modulating growth factor expressions and facilitating earlier hair follicle transitions in treated mice.
2 citations
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January 2006 in “PubMed” This study found that topical application of carpronium chloride led to arteriolar vasodilation and increased blood flow in rat mesenteric arterioles, without affecting systemic blood pressure.
1 citations
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September 2023 in “Journal of cosmetic dermatology” This study suggests that Silybum marianum flower extract may promote hair growth and reduce hair loss by increasing proliferation and VEGF production in dermal papilla cells and suppressing cell senescence.
July 2023 in “Pharmacognosy Magazine” This study found that Cerasus serrulata extracts, when obtained through specific methods, demonstrate significant antioxidative and antibacterial properties, as well as potential anti-alopecia effects in a mouse model, potentially making them useful supplements for these purposes.
March 2024 in “Korean Journal of Pharmacognosy” This study found that Nymphaea caerulea flower extract may improve scalp condition by reducing sebum production, inhibiting inflammation and microbial factors, and decreasing cortisol and vascular permeability.
May 2025 in “Journal of Clinical Medicine” This study suggests that women with alopecia have decreased microcirculation oscillations, which may imply neuroinflammation as a factor in the disease's pathogenesis.
April 2023 in “Pharmacognosy Magazine” In a study using a mouse model, Cerasus serrulata flower extracts significantly increased β-catenin and VEGF expression, promoting hair blackening and suggesting potential as a treatment for premature greying.
1 citations
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July 2020 in “Journal of The American Academy of Dermatology” This review discusses the potential mechanisms by which intradermal botulinum toxin may affect androgenetic alopecia but notes that high-evidence clinical trials have yet to show conclusive results.
27 citations
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October 2020 in “Biomedicine & Pharmacotherapy” This study found that transplanting hair follicle bulge-derived stem cells in rats enhanced skin regeneration during expansion by differentiating into several skin-related cells and increasing the expression of growth factors.
14 citations
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December 2003 in “Medical Hypotheses” This paper proposes a new hypothesis that androgenic hair loss may be caused by changes in scalp vasculature due to androgen effects, but reports no new experimental results.
12 citations
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June 2011 in “Han-guk sikpum gwahakoeji/Han'gug sigpum gwahag hoeji/Han-guk sikpum gwahak hoeji” This study found that MBN, an herbal extract fermented by Lactobacillus plantarum, promoted hair growth and increased related gene expression in C57BL/6 mice.
June 2026 in “Journal of Cutaneous and Aesthetic Surgery” This review proposes an anatomy-based framework for understanding recipient site scalp necrosis in hair transplantation, emphasizing regional vascular vulnerability and surgical factors, but does not provide new clinical results.
This study found changes in the PGI2 pathway, especially in gene and protein expression, in diabetic mice, but did not observe PGI2-dependent vasomotor dysfunction.
November 2008 in “Medical Hypotheses” The conclusion suggests a new treatment for infantile hemangiomas and a potential target for hair loss treatment.
January 1996 in “Lasers in Surgery and Medicine” This letter to the editor by Walter P. Unger discusses topics related to hair transplantation and reports no new research findings.
1 citations
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April 2017 in “Journal of Investigative Dermatology” In this study, D-OCT imaging revealed distinct structural and vascular changes in patients with frontal fibrosing alopecia, highlighting the technique's potential for diagnosing and monitoring the condition's activity.
July 2023 in “Clinical, cosmetic and investigational dermatology” In this study, reflectance confocal microscopy was used to diagnose periorificial dermatitis, revealing specific skin changes such as hair follicle dilatation, increased vascular density, and inflammation, which help distinguish it from similar conditions.
January 2013 in “Российский журнал кожных и венерических болезней” This study found that intradermal injections of group B vitamins and cystin B6 complex improved scalp circulation, supported hair growth, and reduced hair loss in patients with diffuse alopecia.
January 2022 in “Stem cell biology and regenerative medicine” This review explores the complex interactions between hair follicle stem cells and surrounding structures that are essential for understanding hair regeneration, reporting no new experimental results.
April 2021 in “Journal of Cosmetic Dermatology” Stem cell treatment improved hair density in female hair loss patient.
February 2010 in “Journal of The American Academy of Dermatology” A woman's nail separation was likely caused by poor blood flow, and a treatment for similar conditions might help.
June 2004 in “Dermatologic Surgery” This study outlines a technique for hair transplantation that maintains natural hair flow and density by mimicking natural hair direction and angle without accelerating hair loss in the recipient area.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This study elucidates a mechanism for male pattern baldness involving tension in scalp muscles that leads to reduced blood flow and hypoxia around hair follicles, proposing a multi-targeted therapeutic approach.
25 citations
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January 2002 in “Folia Pharmacologica Japonica” This article reviews the proposed mechanism of minoxidil in treating androgenetic alopecia, suggesting it may prolong the anagen phase by modulating cell growth factors and vascular activity, but reports no new results.
1 citations
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October 2025 in “Current Issues in Molecular Biology” This research found that escin, when applied topically, enhances blood flow in human skin and promotes changes in endothelial cell signaling pathways, suggesting potential benefits for improving cutaneous microcirculation.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study developed a dissolvable microneedle system loaded with nanozymes and minoxidil that enhanced hair regeneration in androgenetic alopecia mouse models by improving blood flow, reducing reactive oxygen species, and increasing cell proliferation compared to minoxidil alone.
5 citations
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June 2024 in “Pharmacological Research” This study identified neuropilin-1 as the receptor for FOL-026 and showed that it stimulates angiogenesis and cell growth, suggesting potential for vascular repair and enhanced angiogenesis therapies.