In this study, human hair dermal papilla cells were incubated with varying concentrations of umbilical cord-derived mesenchymal stem cell exosomes or minoxidil, and cell proliferation was assessed, showing significant results compared to the control.
In this study, human umbilical cord mesenchymal stem cell-derived exosomes were found to promote the growth of human hair dermal papilla cells, partly by enhancing AKT-dependent signaling pathways, suggesting a potential role in treating hair loss.
November 2023 in “Cell Biology International” This study investigated the effects of exosomes from human umbilical cord mesenchymal stem cells on hair loss in mice with alopecia areata, emphasizing the potential of these easily isolated and stored exosomes for research and clinical treatment.
14 citations
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February 2020 in “Stem Cells International” This study reported that a single local subcutaneous infusion of mesenchymal stromal cells from the human umbilical cord promoted wound healing, improved blood circulation, and reduced wound size in patients with chronic wounds without significant adverse effects over one year.
10 citations
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May 2024 in “npj Regenerative Medicine” This review discusses the role of umbilical cord-derived mesenchymal stromal cells in skin rejuvenation and reports no new clinical results; it emphasizes their potential in delaying skin aging.
8 citations
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June 2021 in “International Journal of Molecular Sciences” In this study, UCMSC exosomes showed protective effects against cisplatin-induced hearing loss in mice by improving hearing and promoting cochlear tissue repair.
4 citations
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September 2023 in “Stem cell research & therapy” In this study, umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles were found to improve wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis and reducing oxidative stress levels.
3 citations
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December 2023 in “Cell proliferation” This review suggests that the umbilical cord-derived mesenchymal stem cell secretome presents a promising approach for skin regeneration and wound healing due to its multiple therapeutic properties, highlighting its potential over traditional treatments for conditions like chronic wounds and alopecia.
July 2024 in “Acta Histochemica” This study investigates the potential of umbilical cord mesenchymal stem cells exosome (UCMSC-Exos) to promote hair growth, focusing on its mechanisms of action, though specific results are not reported.
February 2023 in “Research Square (Research Square)” This study found that ApoEVs derived from mesenchymal stem cells improved cutaneous wound healing in diabetic mice by inhibiting macrophage pyroptosis and reducing oxidative stress levels.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that exosomes derived from human umbilical cord mesenchymal stem cells enhanced the growth of human hair dermal papilla cells by promoting cell cycle progression and activating PI3K and Akt-dependent pathways, indicating potential for hair loss treatment.
May 2024 in “Cytotherapy” In this study, a 40-year-old man with hair loss showed complete hair regrowth and no relapse 24 weeks after receiving umbilical cord mesenchymal stem cell and secretome injections, highlighting their potential for alopecia treatment, although further research involving larger populations is needed.
January 2026 in “Asian Journal of Pharmaceutical and Clinical Research” This review discusses the potential of umbilical cord blood and umbilical cord-derived stem cells in treating various chronic diseases by highlighting their regenerative abilities and ethical advantages as well as the translational challenges and clinical implications.
5 citations
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April 2024 in “Journal of Ovarian Research” This study found that in mice with premature ovarian insufficiency, miR-21 enhances ovarian function recovery following umbilical cord-derived mesenchymal stem cell transplantation by influencing specific cellular signaling and immune pathways.
July 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that using exosomes derived from thrombin-pretreated umbilical cord mesenchymal stem cells significantly accelerated wound healing and improved skin regeneration in a mouse model, highlighting their potential as a cell-free therapy for skin injuries.
606 citations
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January 2016 in “International Journal of Cell Biology” This review outlines recent advances in stem cell and tissue engineering technologies in regenerative medicine and wildlife conservation, reporting no new clinical results.
January 2026 in “China National GeneBank DataBase” This study found that human hair follicle-derived mesenchymal stem cells demonstrated enhanced wound healing capabilities compared to umbilical cord-derived stem cells in laboratory and animal models.
132 citations
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June 2016 in “Cell and Tissue Research” This review discusses recent advancements in scar reduction techniques, highlighting promising therapeutic targets and the role of Wnt/β-catenin signaling in promoting scarless wound healing, but reports no new clinical results.
This review examines the potential of stem cells and their derived products, such as exosomes and conditioned media, in improving burn wound healing but presents no new clinical data.
4 citations
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May 2002 in “Therapeutische Umschau” AGA treated with finasteride, minoxidil, and hair transplantation.
3 citations
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May 2002 in “Therapeutische Umschau” This article discusses the challenges in diagnosing and treating diffuse hair loss in women and emphasizes the importance of distinguishing between androgenetic alopecia, chronic telogen effluvium, and psychogenic pseudo effluvium, but reports no new clinical results.
1 citations
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December 2005 in “Therapeutische Umschau” This article reviews anti-aging strategies in dermatology, emphasizing the role of skin as a model for studying aging and promoting preventive and therapeutic interventions, but it does not present new findings.
1 citations
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May 2002 in “Therapeutische Umschau” This review discusses common hair diseases in children, highlighting diagnostic tools and treatments, but reports no new clinical results.
1 citations
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August 1984 in “Therapeutische Umschau. Revue thérapeutique” This article reviews treatments for facial hypertrichosis and hirsutism and reports no new clinical findings; the authors highlight the potential of laser and pulsed flash-light systems for permanent hair removal.
May 2002 in “Therapeutische Umschau” This article reviews existing treatments for hypertrichosis and hirsutism, noting that while eflornithine is a promising new option, the efficacy of systemic antiandrogens remains unproven in modern clinical studies.
April 1999 in “Therapeutische Umschau” This review discusses androgenic alopecia and related hair disorders, focusing on their pathogenesis and treatment strategies, and reports no new clinical findings.
January 2020 in “Journal of Cutaneous and Aesthetic Surgery” The conference improved skills and knowledge in skin and aesthetic surgery.
12 citations
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January 2015 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses the nocebo effect in dermatology, highlighting its mechanisms, implications, and strategies to manage it, but does not provide new clinical research findings.
47 citations
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February 2021 in “Pharmacological research” This review discusses the potential of endogenic and exogenous exosomes in dermatology and cutaneous aesthetics, highlighting their capacity to repair and rejuvenate skin tissue, but reports no new experimental results.
41 citations
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September 2010 in “Journal of dermatological science” This study suggests that mesenchymal stem cell-induced dermal papilla-like tissues can generate new hair follicles in mice, indicating potential for developing hair cell therapy using stem cells.