15 citations
,
January 2019 in “International Journal of Women's Dermatology” This review discusses clinical presentations and interventions for alopecia in women of color, highlighting the importance of early recognition and treatment but providing no new clinical results.
13 citations
,
June 2018 in “Journal of Womens Health” This study found that in women with PCOS, suppressive therapy using spironolactone plus oral contraceptives improved hirsutism more effectively than either treatment alone, with initial scores predicting success.
3 citations
,
April 2019 in “Hormone and Metabolic Research” This study found that women with polycystic ovary syndrome have higher insulin resistance and lower serum high-molecular weight adiponectin, which may play a role in the condition's pathogenesis.
2 citations
,
May 2023 in “JAAD Case Reports” This article discusses the lack of information on central centrifugal cicatricial alopecia's manifestations in Black men and reports no new clinical findings; the authors emphasize the need for further study in this population.
1 citations
,
July 2025 in “Journal of the National Medical Association” This study observed that patients newly diagnosed with alopecia areata frequently experience mental health issues, with anxiety and depression being the most common, highlighting the importance of integrated medical and psychological care for these individuals.
1 citations
,
December 2011 in “Journal of the American Academy of Dermatology” Using hair oil/grease may be linked to dandruff in African American girls.
February 2020 in “İstanbul medical journal” This study evaluated the effects of metformin, ethinyl estradiol/cyproterone acetate (EE/SA), and their combination on carotid intima-media thickness and various cardiovascular markers in patients with polycystic ovary syndrome.
September 2023 in “International Research Journal of Modernization in Engineering Technology and Science” This article reviews the growing interest and potential health benefits of nutraceuticals, especially herbal products, highlighting their role in maintaining health, preventing diseases, and improving quality of life, while also discussing developments in nutraceutical research and challenges related to aging skin.
July 2020 in “Journal of The American Academy of Dermatology” This article proposes expanding dermatologic care through barbershops to improve health access and trust among Black men, particularly for conditions like pseudofolliculitis barbae and acne keloidalis nuchae; it reports no new clinical findings.
114 citations
,
January 2007 in “International Journal of Dermatology” This study found that caffeine can stimulate hair growth in vitro and counteract testosterone-induced growth suppression in hair follicles from male AGA patients.
694 citations
,
April 2000 in “Nature genetics” This study found that Msx2-deficient mice exhibit skull and bone formation defects similar to those seen in human MSX2-related conditions, highlighting the gene's importance in skeletal and organ development.
128 citations
,
August 2020 in “Cell stem cell” In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.
100 citations
,
August 2008 in “American Journal Of Pathology” This study found that epidermal VEGF is crucial for maintaining skin barrier function in mice and may help explain psoriasis development following skin trauma due to its effects on angiogenesis and hyperplasia.
42 citations
,
January 2011 in “European Journal of Dermatology” In this study, higher scores of HOMA-IR and FIRI suggested that male patients with early-onset androgenetic alopecia may have insulin resistance, although no significant differences in metabolic syndrome were found compared to controls.
40 citations
,
April 1999 in “Journal of Histochemistry & Cytochemistry” In this study, the researchers identified the specific subcellular localization of the protein S100A3 in the endocuticle and cortex of human hair shafts.
40 citations
,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the S100A3 gene is exclusively expressed in hair follicle cells differentiating into hair shaft components in mice, suggesting its important role in hair formation.
36 citations
,
April 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This article reviews the role of vasoactive intestinal peptide in maintaining immune privilege in hair follicles and does not report new findings; the authors propose it as essential for immune homeostasis in alopecia areata.
33 citations
,
January 2019 in “Acta Dermato Venereologica” This case report suggests potential effectiveness of dupilumab for alopecia areata, though hair regrowth may result from indirect effects on inflammation in atopic dermatitis.
27 citations
,
August 2021 in “Journal of Autoimmunity” This study found that human dermal γδT-cells can act as stress sentinels and potentially trigger autoimmune responses toward stressed hair follicles, resembling features of alopecia areata.
26 citations
,
September 2012 in “Journal of The American Academy of Dermatology” This study observed that patients with rapidly progressive alopecia areata may have a favorable prognosis regardless of treatment, and regenerated vellus hairs were linked to higher improvement or cure rates.
24 citations
,
November 2019 in “Experimental Dermatology” This review synthesizes current research on PPAR-γ signaling in hair follicle biology and its potential role in treating hair growth disorders like scarring alopecia and hirsutism, but reports no new clinical results.
24 citations
,
March 2009 in “Archives of dermatological research” This study found that a combination therapy of oral corticosteroid and oral PUVA led to scalp hair regrowth in patients with intractable alopecia totalis and universalis within two months.
23 citations
,
September 2020 in “Journal of Dermatological Science” This pilot study suggests that skin-resident γδT-cells may play a significant role in the early stages of alopecia areata pathogenesis, indicating a potential new target for therapeutic management.
23 citations
,
December 2010 in “Journal of Dermatology” In this study, oral finasteride improved the quality of life for male patients with androgenetic alopecia, but it did not significantly reduce anxiety or correlate with reported anxiety levels.
21 citations
,
March 2018 in “American Journal Of Pathology” In this study, it was observed that NIPAL4 mutations linked to autosomal recessive congenital ichthyosis lead to abnormal skin barrier function due to cytotoxic effects disrupting lipid structure and organization, which topical treatments only partially ameliorated.
20 citations
,
February 2016 in “American Journal of Pathology” This study indicates that the OVOL1-OVOL2 axis may play a significant role in hair follicle differentiation and growth, potentially serving as therapeutic targets for hair disorders like alopecia and in the tumorigenesis of pilomatricoma.
14 citations
,
January 2014 in “Anais Brasileiros de Dermatologia” This study found that low BMI may increase the risk of developing chilblains in individuals exposed to cold weather, with many patients experiencing recurrent lesions each winter.
13 citations
,
March 2014 in “Cutaneous and Ocular Toxicology” This study found that while isotretinoin lowered levels of female hormones in patients with severe acne, it did not significantly impact ovarian reserve function.
13 citations
,
November 2012 in “Journal of The European Academy of Dermatology and Venereology” This study found that topical clobetasol propionate cream provided a modest improvement in hair regrowth for alopecia areata patients, though those with atopy had higher relapse rates after treatment completion.
13 citations
,
May 2012 in “Cutaneous and ocular toxicology” In this study, researchers found no significant differences in vitamin B12, folate, and homocysteine metabolism between patients with alopecia areata and controls, suggesting no association with vitamin B12 deficiency.