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    Glossary 11β-Hydroxysteroid Dehydrogenase Type 1

    enzyme converting inactive cortisone to active cortisol

    11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) is an enzyme that converts inactive cortisone into active cortisol, a hormone involved in stress response, metabolism, and immune function. This enzyme is found in various tissues, including the liver and adipose tissue, and plays a role in conditions like obesity, diabetes, and potentially hair loss due to its influence on local cortisol levels.

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    1. 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors 2004
    2. Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids Endocrine, metabolic & immune disorders. Drug targets · 2006 · 26 citations
    3. 17 beta-hydroxysteroid dehydrogenase 3 deficiency in the Mediterranean population. PubMed · 2006 · 46 citations
    4. Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin 2001 · 196 citations
    5. Identifying 17-β-HSD3 Deficiency in Patients with Karyotype 46,XY Misdiagnosed with Androgen Insensitivity Syndrome: A Pediatric Case Report American Journal of Case Reports · 2025
    6. Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands Journal of Investigative Dermatology · 1998 · 45 citations
    7. A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention Cosmetics · 2024
    8. Gene expression of type 2 17β hydroxysteroid dehydrogenase in scalp hairs of hirsute women Steroids · 2003 · 28 citations
    9. Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome Nature Clinical Practice Endocrinology & Metabolism · 2005 · 69 citations
    10. Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin Journal of Investigative Dermatology · 2010 · 119 citations
    11. 5α-Reductase activity in the human hair follicle concentrates in the dermal papilla Archives of Dermatological Research · 1998 · 41 citations
    12. Current evidence for the involvement of sex steroid receptors and sex hormones in benign prostatic hyperplasia Research and Reports in Urology · 2019 · 26 citations
    13. Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone Biochemical and Biophysical Research Communications · 2016 · 12 citations
    14. Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome The Journal of Clinical Endocrinology & Metabolism · 2016 · 40 citations
    15. Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites Frontiers in Neuroendocrinology · 2020 · 18 citations
    16. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    17. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    18. 25 years of ERβ: a personal journey Journal of molecular endocrinology · 2021 · 11 citations
    19. In-silico screening of potential anti-androgenic and anti-estrogenic phytocompounds from Saraca asoca for polycystic ovary syndrome treatment Journal of Applied Pharmaceutical Science · 2024
    20. Diagnostic approach to low‐renin hypertension Clinical Endocrinology · 2018 · 29 citations
    21. The control of hair growth: An overview Journal of Investigative Dermatology · 1993 · 62 citations
    22. Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues Molecular and Cellular Endocrinology · 2013 · 48 citations
    23. Gender Differences in Production and Circulating Levels of Sex Hormones and Their Impact on Aging Skin Springer eBooks · 2014
    24. Characterization of minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat European Journal of Pharmaceutics and Biopharmaceutics · 2017 · 19 citations
    25. The role of hair follicles and Edar signalling in cutaneous wound healing Research Explorer (The University of Manchester) · 2016
    26. Plasmaproteinbindung endogener Glucocorticosteroide und deren Einfluss auf Haar- und Speichelkonzentrationen Qucosa (Saxon State and University Library Dresden) · 2017
    27. Minoxidil Acts as an Antiandrogen: A Study of 5α-reductase Type 2 Gene Expression in a Human Keratinocyte Cell Line. PubMed · 2017 · 4 citations
    28. Oestrogen functions in skin and skin appendages Expert Opinion on Therapeutic Targets · 2005 · 68 citations
    29. Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities 2009 · 11 citations
    30. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats Scientific reports · 2018 · 28 citations