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The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Finasteride doesn't affect erections much, but may decrease libido in men.

Testosterone helps human pancreatic cells increase insulin release.

Dutasteride effectively treats benign prostatic hyperplasia and may reduce prostate cancer risk.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Congenital Adrenal Hyperplasia is a rare inherited disease causing hormone imbalances, affecting growth, fertility, and heart health, diagnosed through blood tests and treated with medication and lifestyle changes.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

Chaga mushrooms contain compounds that may promote hair growth better than common treatments.

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

Rice bran extract might help prevent hair loss.

The study created a new method to test drugs that affect hormone processing in skin.

New compounds may help treat prostate cancer by reducing cell growth.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Different human traits like skin color and hair type vary between populations due to genetic adaptations to the environment.

Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

Compound 4 is a promising treatment for hair loss with low toxicity.