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Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Targeting colon cancer stem cells might lead to better treatment results.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Targeting and modifying the stem cell niche can improve regenerative therapies.

BAY 43-9006 helps control kidney cancer growth but doesn't significantly increase overall survival.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

Aging causes skin stem cells to work less effectively.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Interferon, especially alfa interferon, is an effective treatment for cutaneous T-cell lymphoma with manageable side effects.

BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.

Layer-by-Layer self-assembly is promising for biomedical uses like tissue engineering and cell therapy, but challenges remain in material safety and process optimization.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Nanoparticle systems make cancer treatment less toxic.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.