November 2025 in “British Journal of Pharmacology” This study found that inositol hexaphosphate significantly reduced hearing threshold shifts and outer hair cell loss in various sensorineural hearing loss mouse models, suggesting potential for otoprotective use.
October 2025 in “Clinical Chemistry” This study found that combining Juniperus communis extract with 5-Fluorouracil inhibited oral cancer cell growth more effectively than 5-FU alone, inducing cancer cell death and reducing drug resistance by affecting key cellular pathways and proteins.
September 2025 in “Plants” In this study, the wood essential oil of *Juniperus morrisonicola* exhibited significant anti-inflammatory activity, notably inhibiting nitric oxide production in stimulated macrophages, and showed cytotoxic effects against liver cancer cells, suggesting its potential for drug development and eco-friendly applications.
This study found that exosomes derived from human umbilical cord mesenchymal stem cells effectively promoted growth in human hair dermal papilla cells, implicating the PI3K and Akt pathways as potential targets for treating hair loss.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that exosomes derived from human umbilical cord mesenchymal stem cells enhanced the growth of human hair dermal papilla cells by promoting cell cycle progression and activating PI3K and Akt-dependent pathways, indicating potential for hair loss treatment.
In this study, human hair dermal papilla cells were incubated with varying concentrations of umbilical cord-derived mesenchymal stem cell exosomes or minoxidil, and cell proliferation was assessed, showing significant results compared to the control.
March 2025 in “Journal of Science Natural Science” This study successfully synthesized acetyl tetrapeptide-3 on a laboratory scale with over 56% yield and 100% purity, supporting its use in developing hair loss and scalp care products.
October 2024 in “Dermatologica Sinica” This case report describes a 21-year-old male diagnosed with Crohn's disease and ulcerative pyoderma gangrenosum presenting with diverse extraintestinal symptoms, and highlights the success of a multi-drug treatment regimen including steroids and infliximab in improving clinical outcomes, though hematochezia was initially persistent.
July 2024 in “Journal of Investigative Dermatology” Hair follicles are crucial for maintaining skin barrier function.
January 2024 in “Indian Journal of Pharmaceutical Sciences” In this laboratory study, researchers found that a methanol extract of peach kernel improved the growth and viability of human hair follicle dermal papilla cells, suggesting its potential efficacy for hair growth and care through cell proliferation and signaling pathways activation.
In this study, human umbilical cord mesenchymal stem cell-derived exosomes were found to promote the growth of human hair dermal papilla cells, partly by enhancing AKT-dependent signaling pathways, suggesting a potential role in treating hair loss.
November 2023 in “BMC women's health” In this study, certain haircare practices and age factors were found to be associated with the occurrence and severity of traction alopecia among women in Yaoundé.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that neonatal Regulatory T cells are crucial for maintaining PPARγ signaling in hair follicles, which supports melanocyte stem cell function and skin pigmentation during early postnatal development.
September 2023 in “Frontiers in Medicine” This study observed that in the bald scalps of male patients with androgenetic alopecia, there was a significant downregulation of the PPAR signaling pathway, suggesting reduced adipogenesis potentially influencing hair cycling processes.
April 2023 in “Dermatologica Sinica” This review examines the effects of sex hormones on hair growth and the pathogenesis of related hair disorders, highlighting current management benefits and controversies but reporting no new results.
This research reports that after genotoxic stress from ionizing radiation or chemotherapy, hair follicles can utilize progenitor cells from transit-amplifying compartments, not quiescent stem cells, for repair, suggesting a potential therapeutic approach to prevent therapy-induced hair loss by activating these progenitors.
This study suggests that targeting the activation of transit-amplifying cell-derived progenitor cells may help prevent hair loss from chemotherapy and radiotherapy by promoting hair follicle regeneration.
In this study, various cellular responses and signaling pathways were examined in hair follicles after exposure to ionizing radiation, including the effects of Wnt3a treatment, with findings noted in apoptosis, DNA damage, and differentiation processes.
Results are not reported in this study, which investigated the effects of radiation on hair follicles and evaluated various cellular responses and signaling pathways, particularly focusing on WNT signaling and the impact of Wnt3a treatment.
January 2023 in “Biocell” The study found that safflower extract may help protect human follicle dermal papilla cells from cisplatin-induced damage, suggesting its potential as an adjuvant in chemotherapy to mitigate hair follicle cell damage.
September 2022 in “Dermatology and therapy” This review summarizes current evidence on the use of contact immunotherapy, excluding alopecia areata, for various skin diseases, discussing its safety, efficacy, and the underlying mechanisms as reported from studies in the PubMed database.
January 2022 in “International Journal of Medical Sciences” This study investigated the effects of cedrol on colorectal cancer and found that it inhibited cell proliferation and induced cell cycle arrest and apoptosis in cell models, while in vivo, it suppressed cancer progression and improved survival at a well-tolerated dose.
August 2021 in “Journal of maternal and child health” This study found that obesity reduced the risk of anemia but increased the risk of PCOS among women of reproductive age.
March 2021 in “Research Square (Research Square)” This study found that stress is likely the main cause of symmetrical alopecia in Formosan macaques, with higher stress hormone levels observed in affected individuals.
April 2019 in “Journal of Investigative Dermatology” This study found that, in mice, different precursor populations give rise to Merkel cells in hairy versus glabrous skin, but their formation is controlled by a common genetic program involving FGFR2 signaling.
March 2019 in “Applied sciences” This case report suggests that 1064 nm picosecond Nd:YAG laser therapy may effectively improve alopecia totalis when used as an alternative adjuvant treatment, as demonstrated in a split-scalp study showing better results than steroid treatment alone.
July 2012 in “European journal of cancer” This study demonstrated that switching aE-catenin to aT-catenin in murine skin substantially rescued hyperproliferative and pre-cancerous conditions, but led to partial baldness, indicating potential functional discrepancies.
August 2011 in “Journal of the Chinese Medical Association” This paper discusses radiation exposure management following the Fukushima nuclear disaster, emphasizing stable iodine prophylaxis for high-risk populations and the need for public education, without presenting new clinical findings.
December 2008 in “中華皮膚科醫學雜誌” This case report describes a 35-year-old Taiwanese man whose hair loss improved significantly after treatment for syphilis, suggesting a link between his condition and the infection.
June 2002 in “Dermatologic Surgery” This study found that follicular unit density in bald Chinese patients is lower compared to Caucasian patients, with an average implantation density of 30 FUs/cm² achieving about 40% of normal hair density for frontal hairline reconstruction.