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    Glossary Transit Amplifying Cells

    cells derived from stem cells that rapidly divide before specializing

    Transit Amplifying Cells (TACs) are a type of progenitor cell that arise from stem cells and undergo a limited number of rapid divisions before differentiating into specialized cells. In the context of hair biology, TACs play a crucial role in the hair growth cycle by proliferating to produce the cells that form the hair shaft and surrounding structures.

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    1. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007 · 153 citations
    2. In Vitro Differences Between Keratinocyte Stem Cells and Transit-Amplifying Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2005 · 52 citations
    3. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research · 2017 · 38 citations
    4. Emerging roles of transit‐amplifying cells in tissue regeneration and cancer Wiley Interdisciplinary Reviews-Developmental Biology · 2017 · 32 citations
    5. Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    6. 1503 Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest 2023
    7. Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    8. Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    9. Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest bioRxiv (Cold Spring Harbor Laboratory) · 2022
    10. Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog Genes & Development · 2016 · 75 citations
    11. Hair Follicle Transit-Amplifying Cells Phagocytose Dead Cells after Radiotherapeutic and Chemotherapeutic Injuries for Timely Regeneration Journal of Investigative Dermatology · 2023 · 3 citations
    12. Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    13. 701 Signaling networks between stem cell precursors, transit amplifying progenitors, and their niche in developing hair follicles Journal of Investigative Dermatology · 2016
    14. 560 Isolation of an “early” transit amplifying keratinocyte population in interfollicular human epidermis: a role for CD271 receptor Journal of Investigative Dermatology · 2022
    15. Location and phenotype of human adult keratinocyte stem cells of the skin Differentiation · 2004 · 233 citations
    16. Multi‐tasking epidermal stem cells: Beyond epidermal maintenance Development, Growth & Differentiation · 2018 · 23 citations
    17. A single type of progenitor cell maintains normal epidermis Yearbook of Dermatology and Dermatologic Surgery · 2008
    18. Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells Genes & development · 2005 · 384 citations
    19. 331 Characterisation of interfollicular stem cells and early TA cells during the transition from infant to child skin Journal of Investigative Dermatology · 2021
    20. 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion Journal of Investigative Dermatology · 2022
    21. 732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion Journal of Investigative Dermatology · 2022
    22. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017 · 12 citations
    23. 751 Thymic stromal lymphopoeitin controls hair growth 2022
    24. EP-2270: Novel protective effect of prostaglandin for timely hair follicle regeneration from radiation injury Radiotherapy and Oncology · 2018
    25. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations
    26. Getting to the Core of the Dermal Papilla Journal of Investigative Dermatology · 2017 · 21 citations
    27. A two-phase model of skin epidermal stratification: lessons from centrosomes bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    28. Thymic stromal lymphopoietin controls hair growth Stem cell reports · 2022 · 5 citations
    29. Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity Cell · 2025
    30. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices Cell · 2017 · 214 citations