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30 / 774 resultsresearch Exploring machine learning strategies for single-cell transcriptomic analysis in wound healing
This review highlights recent research using single-cell RNA sequencing and machine learning in wound healing, revealing significant insights into fibroblast diversity, immune cell dynamics, and the spatial organization of cells, which may transform therapeutic strategies for chronic wounds, fibrosis, and tissue regeneration.
research Bibliometric evaluation of Anais Brasileiros de Dermatologia (2013-2022)
This article critically analyzed the trajectory of the Anais Brasileiros de Dermatologia over the past decade, reporting that the journal has experienced notable growth in bibliometric indices, suggesting a successful editorial policy and increased international visibility compared to Brazilian and other international dermatology journals.
research When to expect scalp hair regrowth during treatment of severe alopecia areata with baricitinib: insights from trajectories analyses of patients enrolled in two phase III trials
In this study, researchers identified subgroups of patients with severe alopecia areata treated with baricitinib who experienced early, gradual, or late hair regrowth, finding that response was influenced by baseline disease severity and duration of hair loss.
research There are early, gradual and late responders for scalp hair regrowth in patients with alopecia areata treated with baricitinib
Different people with severe hair loss respond to baricitinib treatment at different times, with some showing improvement early, some gradually, and others later.
research Trajectory of hiPSCs derived neural progenitor cells differentiation into dermal papilla-like cells and their characteristics
In this study, researchers differentiated human induced pluripotent stem cells into dermal papilla-like cells and observed gene expression dynamics during five stages of dermal differentiation, demonstrating the potential of these cells to interact with epidermal cells in functional assays.
research The Influence of Herbal Tea Ingredients on Hair Condition: A Critical Review
This study highlights a novel herbal tea blend that may improve hair health and provide anti-aging benefits, though its efficacy requires further scientific validation.
research Sparse haplotype-based fine-scale local ancestry inference at scale reveals recent selection on immune responses
This study found that faster algorithms for inferring ancestry in genomic data can better capture historical and functional insights into genome variation than traditional methods in large datasets like the UK Biobank.
research Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying
This study used single-cell RNA sequencing to create a detailed atlas of human scalp hair follicles and found that early-stage hair graying involves matrix hair progenitor depletion linked to P53 pathway activation.
research Spatio-temporal regulation of gene expression defines subpopulations of epidermal stem cells
This narrative review discusses the discovery of plasticity in epidermal stem cells using single-cell transcriptomics, but reports no new results; it highlights the potential implications for regenerative medicine.
research Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration
In this study, topical quercetin was found to stimulate hair follicle growth and promote microvascular regrowth in mice, suggesting its potential for hair regrowth strategies.
research Does Nirmatrelvir/Ritonavir Influence the Immune Response against SARS-CoV-2, Independently from Rebound?
This study reported that COVID-19 patients treated with nirmatrelvir/ritonavir had lower anti-spike IgG levels and different cytokine patterns compared to those not receiving antiviral treatment, suggesting early antiviral use may alter immune response by reducing viral load and antigen presentation.
research Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers
This study highlights multiple factors contributing to hair graying, such as oxidative damage, melanocyte changes, and genetic influences, and suggests that repigmentation may be temporarily reversible, offering potential targets for future treatments while urging caution when applying mouse model findings to humans.
research Intrinsic and Extrinsic Factors Associated with Hair Graying (Canities) and Therapeutic Potential of Plant Extracts and Phytochemicals
This review explored the causes of hair graying and evaluated how plant-derived extracts and phytochemicals might alleviate it, noting that certain compounds showed potential in enhancing melanocyte function, reducing oxidative stress, and influencing stress-related pathways based on experimental evidence.
research In the Empire of Images: Preface to the Tenth Anniversary Edition
This article discusses the pervasive presence and influence of advertisements in daily life but does not provide new research findings.
research Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
This study found that the maternal nutritional status during early pregnancy significantly influenced epigenetic changes in offspring, as maternal diet altered DNA methylation at human metastable epialleles.
research Deciphering the cellular landscape and genetic underpinnings of fiber diameter determined by dermal papilla cells in fine-wool sheep
In this study, researchers used single-cell RNA sequencing to map the hair follicle microenvironment in fine-wool sheep, identifying specific cell types and gene expressions that influence wool fiber diameter, with dermal papilla cells playing a significant role in hair follicle development.
research Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China
This study found that ancient and modern Chinese goats share close genetic ties, originating from the Fertile Crescent, with genetic divergence influenced by China's climatic divisions.
research A genetically informed brain atlas for enhancing brain imaging genomics
This study concluded that the GIANT brain atlas, which integrates genetic and neuroanatomical variations, provides a more accurate representation of brain structure than traditional neuroanatomical atlases, allowing for better exploration of genetic influences on the brain.
research From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization
In this study, researchers suggest that hair follicle miniaturization in conditions like androgenetic alopecia may result from impaired conversion of quiescent stem cells to progenitor cells, influenced by the follicular niche, its collagen network, and various mechanical constraints.
research COPD at the end of life: Predictors of the emotional distress of patients and their family caregivers
This study highlights the interconnected emotional distress between patients with end-stage COPD and their family caregivers, emphasizing that both parties' functional and emotional variables influence each other's distress.
research Molecular modeling and structural characterization of a high glycine–tyrosine hair keratin associated protein
This study presents computational modeling and experimental analysis of the HGT protein KAP8.1, identifying key structural features that may influence hair's response to environmental conditions.
research Elastoinertial effects govern dynamic response of soft hair beds
This study investigated the dynamic mechanical properties of fluid-immersed elastic hair beds under oscillatory shear flows, revealing a nonlinear response influenced by driving frequency and amplitude, which impacts mechanosensory signaling stability in biological processes like vasodilation and ciliary remodeling.
research Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance
This study provides a framework for understanding different types of alopecias based on immune privilege collapse at specific follicular sites, revealing distinct patterns in immune effector programs and stromal influences depending on the alopecia type.
research Progress on genome-wide association studies and selection signature analysis for agronomic traits in Chinese sheep and goats: review
This review summarizes the application of genome wide association studies and selection signature analyses in sheep and goat breeding in China, highlighting genomic regions that influence traits like reproductive performance and body size.
research Dermal niche signaling and epidermal stem cells
This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.
research Automated Machine Learning Analysis of Patients With Chronic Skin Disease Using a Medical Smartphone App: Retrospective Study
This study reported that AutoML effectively modeled itching and pain development, as well as app use, in patients with chronic eczema or psoriasis using a smartphone monitoring app, revealing that factors like BMI, age, and disease activity significantly influenced app engagement.
research The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate
This review summarizes evidence suggesting that metabolism actively influences stem cell fate in intestinal and hair follicle stem cells, rather than being a mere environmental byproduct.
research The spread of antimicrobial resistance in the aquatic environment from faecal pollution: a scoping review of a multifaceted issue
This review discusses how faecal pollution contributes to antimicrobial resistance in surface water and highlights the need for standardized methods and better wastewater management but reports no new clinical results.
research 174 Dermis-hair follicle communication: Extracellular microvesicles signaling for hair regeneration
This study reports that extracellular microvesicles isolated from stimulated dermal fibroblasts enhanced hair follicle growth ex vivo and identified norrin as a novel modulator in hair regeneration processes.