March 2010 in “Ejc Supplements” This study highlights a paradox where valproic acid, known for causing hair loss, may also promote hair growth when applied topically.
8 citations
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January 1989 in “PubMed” This study found that applying minoxidil topically had no recognizable effect on hair follicle growth in newborn mice, though it highlighted apoptosis as a potential marker for hair regression research.
1 citations
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January 2023 in “European Journal of Research in Dentistry” This study found that topical application of tideglusib in a bacterial cellulose-based hydrogel showed positive effects on the healing of palatal wounds in rats.
January 2023 in “Marmara University Open Access System” This study found that tideglusib delivered topically in a bacterial cellulose hydrogel showed positive effects on the wound healing of rat palatal mucosa, as observed through macroscopic, histomorphometric, and immunohistochemical evaluations.
1 citations
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April 2018 in “Journal of Investigative Dermatology” This study found that topical simvastatin induced remission and hair regrowth in a mouse model of alopecia areata, potentially by modulating T cell activity and reducing pro-inflammatory cytokine signaling.
April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that new folate salts in aqueous and lipophilic solutions can penetrate skin and enhance wound healing in vitro by converting metabolically, suggesting their potential for topical application.
June 1996 in “Journal of Dermatological Science” Vitamin D3 applied to mouse skin caused more wrinkles and sagging due to changes in the skin's outer layer.
49 citations
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April 2012 in “Phytotherapy Research” This study found that topical Rosmarinus officinalis leaf extract improved hair regrowth in mice and inhibited androgen-associated mechanisms involved in hair loss.
1 citations
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February 2017 in “Journal of pharmacology & clinical research” This study found that topical gel formulations containing extracts of Eclipta alba and Lippia nodiflora significantly increased hair growth in black mice over 30 days, with a combination of both extracts showing greater effectiveness than either alone.
25 citations
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May 2013 in “Experimental Dermatology” This study found that topical EGF-liposomal solution may protect hair follicles from chemotherapy-induced damage by inducing a catagen-like stage in a mouse model.
5 citations
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January 2007 This study found that topical application of Citrullus colocynthis extracts reduced hair growth initiation and completion times in albino rats and resulted in similar hair follicle anagen phase activation as minoxidil.
May 2026 in “Therapeutic Delivery” This study found that applying a dutasteride-loaded liposome formulation to damp rat skin nearly doubled the drug's follicular accumulation compared to dry skin, suggesting scalp hydration status may significantly impact the drug's topical delivery, especially in follicle-rich areas.
July 2024 in “International Journal of Dermatology Venereology and Leprosy Sciences” This study suggests that topical minoxidil could promote hair regrowth in individuals with alopecia areata by exerting a localized immunosuppressive effect, and that combining minoxidil with other treatments may enhance hair growth outcomes.
This study found that topical application of Sinsun-yukza-hwan extract significantly increased hair density and thickness in a mouse alopecia model and enhanced expression of growth-related genes.
2 citations
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January 2006 in “PubMed” This study found that topical application of carpronium chloride led to arteriolar vasodilation and increased blood flow in rat mesenteric arterioles, without affecting systemic blood pressure.
6 citations
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January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This study found that topical application of triiodothyronine (T3) can induce the transition of hair follicles from the telogen to the anagen phase in mice and stimulate hair shaft growth in vitro.
5 citations
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February 2008 in “Experimental Dermatology” In this study, topical application of Cyclosporin A on mice skin induced hair growth by transitioning follicles from telogen to anagen, but no effect was observed on cultured human hair follicles.
2 citations
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August 2020 in “Natural Product Communications” This study found that the topical application of a mixture of Platycladus orientalis leaf extract and α-terpineol promoted hair growth in mice by inducing early anagen transition and increasing growth factor expressions.
April 2016 in “Journal of Investigative Dermatology” This study found that topical phenylephrine, an α1-AR agonist, significantly reduced hair shedding and increased epilation force threshold in women experiencing traction alopecia during cosmetic procedures.
April 2010 in “The FASEB Journal” This study found that topical application of Korean ginseng berry promoted hair follicle development in mice, with a lower dose proving more effective than a higher dose.
April 2009 in “한국메이크업디자인학회지” This study found that topical geranium rose oil accelerated hair regrowth and promoted hair follicle elongation in a shaving animal model of C57BL/6 mice.
December 1990 in “PubMed” This study found that topical application of 17 alpha-propylmesterolone significantly increased proliferative activity in hair matrix cells in men with androgenetic alopecia.
37 citations
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January 1980 in “PubMed” This study found that topical hair lotions with 17 alpha-estradiol may reduce telogen hair loss in patients with androgenetic alopecia, though they did not lead to new hair regrowth.
23 citations
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November 2007 in “Actas Dermo-Sifiliográficas” This study suggests that topical T3 can induce hair follicles to enter the growth phase and may reverse graying in mice, with in vitro results supporting enhanced hair shaft growth.
23 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that topical minoxidil and diazoxide induced significant hair regrowth in bald macaques, while a steroid 5 alpha-reductase inhibitor prevented baldness in preadolescent macaques.
15 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” In a C3H mouse model, this study found that topical retinoids can significantly alter hair-cycle dynamics by prolonging the anagen phase and shortening the telogen phase, a reaction connected to increased cellular retinoic acid-binding protein levels.
1 citations
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September 2023 in “Pharmacology and Drug Toxicology” In this study with hair-loss-induced rats, topical minoxidil treatment was found to have antioxidant effects in the skin and blood, decreasing oxidative stress markers over a 21-day period, without showing significant hair growth improvement compared to the control group.
March 1985 in “Journal of the American Academy of Dermatology” This research found that topical minoxidil may promote hair regrowth in alopecia areata by stimulating hair follicle epithelium and suppressing certain immune responses, with potential contributions from its vasodilatory effects.
54 citations
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January 2013 in “BMC Complementary and Alternative Medicine” In this study, topical application of Thuja orientalis extract promoted hair growth by inducing the anagen phase and increasing hair follicle size and number in telogenic mice.
27 citations
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July 1982 in “British Journal of Dermatology” The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.