23 citations
,
November 2018 in “International Journal of Molecular Sciences” This study found that deoxyshikonin promoted wound healing in diabetic mice, suggesting it may contribute to wound repair in patients with diabetes.
20 citations
,
January 2003 in “Dermatology online journal” This review discusses the potential of prostaglandin analogs for hair growth and forms of alopecia, and reports no new clinical results.
20 citations
,
December 1995 in “International Journal of Pharmaceutics” Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.
19 citations
,
October 2009 in “Bioorganic & Medicinal Chemistry Letters” This study found that a thyroid hormone receptor ẞ subtype-selective thyromimetic was effective in promoting hair growth in mouse and monkey models when applied topically.
18 citations
,
April 1986 in “International Journal of Cosmetic Science” In this study with stumptailed macaques, topical minoxidil successfully induced hair regrowth on bald scalps and prevented baldness on non-bald scalps, with no observed side effects over nearly three years.
18 citations
,
May 2020 in “Biomolecules” This review discusses spironolactone's new roles in tumor immunosurveillance, DNA repair inhibition, and viral infection suppression, highlighting its potential to extend uses beyond traditional applications, but reports no clinical results.
17 citations
,
April 2017 in “International Journal of Biological Macromolecules” This study found that alginate beads containing monoolein demonstrated promising potential for managing wet wounds by better absorbing excess exudate and delivering adenosine locally, favoring drug localization in damaged porcine skin compared to an aqueous solution without affecting skin viability.
17 citations
,
May 1998 in “Contact Dermatitis” Minoxidil can cause pustular allergic reactions on skin.
13 citations
,
May 2021 in “Plants” This study found that the n-hexane fraction from Leea indica leaves significantly increased hair growth in mice and showed potential as a natural treatment for alopecia.
13 citations
,
October 2013 in “The Journal of Dermatology” This study found that topical cepharanthine increased IGF-I production in human dermal papilla cells, suggesting it may stimulate hair growth and be a promising treatment option for androgenetic alopecia.
12 citations
,
January 2021 in “Journal of Cutaneous and Aesthetic Surgery” This systematic review describes current findings on the use of recombinant epidermal growth factor (rhEGF) for skin aging and wound healing, emphasizing its potential benefits but highlighting the need for more controlled studies to optimize dosing and treatment protocols.
11 citations
,
June 1996 in “Nutrition” Vitamin D3 may prevent hair loss from chemotherapy, but side effects and cancer cell protection are concerns.
11 citations
,
December 2018 in “Assay and Drug Development Technologies” This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.
10 citations
,
December 2019 in “International journal of medicinal chemistry” In this study, researchers found that flavonoid glycosides extracted from Dicerocaryum senecioides leaves significantly promoted hair growth in BalB/c mice, with the shortest hair growth completion time of 19 days compared to the control's 29 days, and dose-dependent results.
10 citations
,
January 1996 in “Journal of Dermatological Treatment” In this study, a standardized 7.5% herbal extract significantly increased hair growth in men with androgenetic alopecia compared to a placebo over a 48-week period.
9 citations
,
July 2021 in “Frontiers in Pharmacology” This study found that intradermal injection of cholesterol-modified siRNA targeting FGF5 or FGF18, or topical application of FGF18-targeted siRNA, effectively influenced hair follicle cycles in mice, suggesting potential benefits for alopecia management.
9 citations
,
August 2014 in “Journal of The Korean Society of Food Science and Nutrition” This study found that Zizyphus jujuba, especially when fermented with Saccharomyces cerevisiae, showed strong antioxidative activity and effectively promoted hair regrowth and prevented hair loss in a mouse model.
8 citations
,
July 2020 in “International Journal of Pharmaceutics” In this study, complexation with cyclodextrins was reported to increase the solubility of FIN for potential use in aqueous formulations for treating male androgenic alopecia.
8 citations
,
August 2019 in “Journal of Drug Delivery and Therapeutics” This study aimed to formulate and evaluate a herbal gel containing Allium cepa extract for its physical properties, such as appearance, viscosity, and spreadability, but it does not report specific results or effectiveness in preventing hair loss.
8 citations
,
June 2024 in “Pharmaceutics” This study found that using elastic nano-liposomes to deliver palmitoylethanolamide improved its transdermal delivery and enhanced its skincare effects, with minimal cytotoxicity and no allergic reactions observed.
7 citations
,
February 2018 in “International Journal of Pharmaceutics” This study found that the cyanoacrylate biopsy method could effectively evaluate drug distribution in hair follicles, suggesting its potential utility for assessing topically applied chemicals targeting hair follicles.
7 citations
,
October 2006 in “Medical hypotheses” UV light might cause excessive hair growth by increasing PGE2 in the skin.
5 citations
,
January 2021 in “Biomedicine & Pharmacotherapy” This study suggests that policosanol may prevent androgenetic alopecia in mice by regulating hormone levels and suppressing premature hair follicle entry into the regression phase.
4 citations
,
January 2016 in “Elsevier eBooks” This chapter reviews different animal models for evaluating wound healing treatments and provides no new experimental results.
4 citations
,
September 2012 in “Journal of dermatological science” The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.
3 citations
,
April 2019 in “Clinical Therapeutics” This study identified 19 genes targeted by 29 potential drugs for topical treatment of chemotherapy-induced alopecia, suggesting avenues for drug repositioning in pharmaceutical research.
3 citations
,
January 2019 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” Korean medicine treatments for alopecia often show partial improvement but need more research for standardized guidelines.
2 citations
,
March 2022 in “Applied sciences” In this study, Lespedeza bicolor extract was found to enhance dermal papilla cell proliferation and extend the anagen phase in mice, suggesting its potential as a treatment for alopecia.
2 citations
,
November 2019 in “Phytotherapy Research” This study found that consuming 100 mg of pea sprout extract daily for 8 weeks significantly reduced hair loss in individuals experiencing excessive hair shedding.
2 citations
,
April 2019 in “Pharmaceutical sciences and research” This study found that lotion containing ethanolic extract of Phyllanthus niruri promoted hair growth in rats, with the addition of 1% menthol enhancing this effect compared to the extract alone.