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GlossaryTopical Treatment (Topical Application)

application of medication directly to skin or mucous membranes

Topical treatment refers to the application of a medication directly to a specific area of the skin or mucous membranes to treat localized conditions. This method is commonly used for skin disorders, including alopecia, where treatments like creams, gels, or solutions are applied to the scalp to promote hair growth or reduce hair loss.

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Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice

research Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice

91 citations, April 2011 in “Journal of Ethnopharmacology”

Polygonum multiflorum extract helps grow hair by activating certain hair growth signals in mice.

research Topical Application of the Synthetic Triterpenoid RTA 408 Protects Mice from Radiation-Induced Dermatitis

61 citations, April 2014 in “Radiation Research”

RTA 408 cream protects mice from radiation skin damage.

research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation

60 citations, January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Applying a specific inhibitor lightens skin and hair color.

research Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation

56 citations, January 2007 in “Pharmaceutical Development and Technology”

Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.

research The Use of Liposomes in the Topical Application of Steroids

33 citations, May 1984 in “Journal of Pharmacy and Pharmacology”

Liposomes are not better than acetone for applying DHT on skin.

research Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin

32 citations, June 2015 in “PLOS ONE”

Olive leaf compound oleuropein helps grow hair in mice.

research Stability of Polylactic Acid Particles and Release of Fluorochromes Upon Topical Application on Human Skin Explants

31 citations, January 2012 in “European journal of pharmaceutics and biopharmaceutics”

PLA particles release their contents differently based on the type of fluorochrome used.

Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent

research Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent

28 citations, December 2005 in “Journal of cosmetic dermatology”

Apple procyanidin applied to the scalp may help grow hair without side effects.

research Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice

24 citations, April 2005 in “The Journal of Dermatology”

Putting ketoconazole on the skin can help mice grow hair.

Topical Application of Cyclosporin A Induces Rapid Remodeling of Damaged Anagen Hair Follicles in Cyclophosphamide-Administered Mice

research Topical Application of Cyclosporin A Induces Rapid Remodeling of Damaged Anagen Hair Follicles in Cyclophosphamide-Administered Mice

24 citations, September 2001 in “Journal of Dermatological Science”

Cyclosporin A helps damaged hair follicles regrow hair quickly.

research Preparation and Evaluation of Minoxidil Gels for Topical Application in Alopecia

22 citations, July 2006 in “Indian Journal of Pharmaceutical Sciences”

Minoxidil gels with higher concentrations are more stable and effective for treating hair loss.

Topical Application of the Wnt/β-Catenin Activator Methyl Vanillate Increases Hair Count and Hair Mass Index in Women with Androgenetic Alopecia

research Topical Application of the Wnt/β-Catenin Activator Methyl Vanillate Increases Hair Count and Hair Mass Index in Women with Androgenetic Alopecia

20 citations, April 2016 in “Journal of Cosmetic Dermatology”

Methyl vanillate spray increases hair count and hair mass in women with hair loss.

research Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine

15 citations, December 2016 in “Advanced Pharmaceutical Bulletin”

The new cream with N-acetyl glucosamine didn't change skin color after 8 weeks.

research Topical Application of Dehydroxymethylepoxyquinomicin Improves Allergic Inflammation via NF-κB Inhibition

15 citations, July 2010 in “Journal of Allergy and Clinical Immunology”

A new cream, DHMEQ, reduces allergic skin inflammation effectively.

research Human Essential Fatty Acid Deficiency: Treatment by Topical Application of Linoleic Acid

14 citations, July 1977 in “PubMed”

Applying linoleic acid to the skin fixed essential fatty acid deficiency symptoms.

research Influence of Nanocrystal Size on the In Vivo Absorption Kinetics of Caffeine After Topical Application

10 citations, July 2021 in “European journal of pharmaceutics and biopharmaceutics”

Nanoparticles sized between 470 and 750 nm are best for delivering substances like caffeine into hair follicles for absorption.

research Lack of Endocrine Systemic Side Effects After Topical Application of Spironolactone in Men

8 citations, April 1988 in “Journal of endocrinological investigation”

Topical spironolactone cream doesn't cause hormone-related side effects in the body.

research Topical Application of Bifidobacterium-Fermented Soy Milk Extract Containing Genistein and Daidzein Improves Rheological and Physiological Properties of Skin

8 citations, February 2005 in “International Journal of Cosmetic Science”

Applying a special soy milk extract on skin can make it more elastic and hydrated.

research Frontal Edema Due to Topical Application of 5% Minoxidil Solution Following Mesotherapy Injections

7 citations, January 2015 in “International Journal of Trichology”

Applying minoxidil on the scalp after mesotherapy injections caused temporary swelling.

research Potential Applications of Topical Oxygen Therapy in Dermatology

7 citations, October 2018 in “Dermatology practical & conceptual”

Topical oxygen therapy may improve treatments for hair loss, acne, and chronic skin diseases with minimal side effects.

research Topical Application of Thymidine Dinucleotide to Newborn Mice Reduces and Delays Development of UV-Induced Melanomas

5 citations, June 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Putting thymidine dinucleotide on newborn mice's skin can delay and reduce skin cancer.

Emollients: Application of Topical Treatments to the Skin

research Effect of Topical Application of Oils of Amla, Coconut, Sarson, and Samsol on Growth of Rabbit's Hair and Sheep Wool

1 citations, November 1981 in “PubMed”

No clear conclusion available.

research Topical Application of Aprepitant Inhibits Erlotinib-Induced Facial Dermatitis and Hair Loss

January 2024 in “Journal of dermatology and skin science”

Topical aprepitant reduces skin rash and hair loss caused by cancer treatment.

research Topical Application of Capsicum Frutescens Leaf Extract as Hair Tonic in Mice (Mus Musculus)

December 2020 in “Jurnal Kedokteran Hewan”

Cayenne leaf extract can effectively promote hair growth.

research Topical Application of Cinnamon (Cinnamomum Burmanii) Essential Oil Has the Same Effectiveness as Minoxidil in Increasing Hair Length and Diameter Size of Hair Follicles in Male White Wistar Rats (Rattus Norvegicus)

March 2018

Cinnamon oil works as well as minoxidil for hair growth.