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In this study, topical administration of secretome hypoxia mesenchymal stem cells gel increased IL-10 and decreased TNF-α gene expression in a fluconazole-induced alopecia-like model in rats, with the 40 μL dose having the most significant effect.

This study found that TNC + fibroblasts are crucial in neuro-immune interactions in various skin diseases, particularly inflammation and tumors, by engaging extensively with immune cells and overexpressing inflammatory genes, suggesting their significant role in skin abnormalities.

In this study, 30 patients with alopecia areata received intralesional methotrexate injections, resulting in significant hair regrowth and decreased levels of lesional TNF-α after three months, suggesting its effectiveness as a treatment.

The article presents three clinical cases of universal alopecia developing during TNF-α inhibitor therapy and discusses possible mechanisms and the role of pro-inflammatory cytokines.

This case report details a child with a specific TNFAIP3 mutation manifesting as a severe SLE/SS phenotype, expanding the known phenotype for this genetic variant.

In this study, individuals with androgenetic alopecia showed higher serum levels of oxidative stress markers and lower levels of antioxidants, indicating disrupted redox balance and suggesting oxidative stress may accelerate hair loss.

TNF-a may not be as involved in certain types of hair loss as previously thought.

In this study, TNF- inhibited hair growth in cultured human hair follicles, while minoxidil did not counteract this effect or stimulate growth.

In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.

This study found that recombinant human leukocyte interferon alfa-2a achieved a 64% overall antitumor response rate in patients with early and advanced cutaneous T cell lymphoma and was generally well-tolerated.

This review discusses the dermatological adverse events from immunosuppressive and anti-TNF therapy in IBD, finding increased risks of non-melanoma skin cancer and other skin conditions, and recommends regular cancer screening.

In this study, only 1 out of 5 patients with anti-TNF-α induced psoriasiform eruptions showed good response to topical treatment, while systemic therapy and discontinuation of anti-TNF-α may prevent scarring alopecia in severe cases.

In this study, weight gain and hair loss were reported as adverse effects of anti-TNF therapy in patients with rheumatic diseases, leading some to discontinue treatment.

This study observed that 6.45% of IBD patients treated with anti-TNF therapy developed severe psoriasiform reactions, with notable cases of alopecia universalis suggesting a potential link to previous alopecia areata.

In this case report, a patient with Crohn's disease experienced alopecia and psoriasiform reactions attributed to anti-TNF therapy, which improved after switching to Ustekinumab.

This study, involving a retrospective analysis of 24 patients in France, found that paradoxical psoriasiform alopecic reactions on the scalp associated with TNFα-targeted therapies for inflammatory bowel disease are rare yet non-scarring, with all patients achieving complete hair regrowth within two months after treatment adjustments.

This study found that hirsutism in women is associated with elevated androgen hormone levels and increased serum TNFα, suggesting a link between androgen-driven inflammatory responses and excessive hair growth.

This study examined the market trends for biologics that have lost patent exclusivity and predicted that drugs like adalimumab, once facing competition, could see price reductions and decreased market share, although the impact on accessibility and total patient use remains unclear.

This study found that dermal papilla cells can induce hair follicle regeneration and maintain growth in vitro and in vivo, with higher ET-1 and SCF expression enhancing this ability.

This study found that mammary resident macrophages play a key role in mammary tissue development by influencing cell division and maintaining mammary stem cell activity through the TNF-α-Cdk1/Cyclin B1 signaling pathway, highlighting their importance in the mammary stem cell niche.

This study found that hydroxytyrosol significantly alleviated acute liver injury in mice by suppressing inflammation and targeting the TNF-α/PI3K/AKT signaling pathway.

This study found that cardamonin can reduce inflammation in TNF-α-stimulated human periodontal ligament cells by suppressing specific cytokines and chemokines and inhibiting key inflammatory signaling pathways.

This study found that mammary resident macrophages regulate mammary epithelium cell division and development, with implications for maintaining mammary stem cell activity and homeostasis.

This study found that a combination of natural compounds (escin, bromelain, ginkgo biloba, and sage miltiorrhiza) reduced platelet adhesion to activated endothelium in laboratory settings by inhibiting adhesion molecule transcription and reducing pro-inflammatory cytokines, potentially preventing initial steps of the coagulation cascade.

This study found that METTL1 is upregulated in papillary thyroid cancer tissues and promotes cancer cell proliferation and metastasis through its tRNA methyltransferase activity.

This study found that using hemocoagulase combined with platelet-rich plasma during total hip replacement surgery led to reduced perioperative blood loss and improved early joint range of motion in osteoarthritis patients.