37 citations
,
June 2017 in “Journal of Investigative Dermatology” This study suggests that the interaction between CXXC5 and Dishevelled is a potential target for promoting hair regrowth and hair follicle formation, offering a new approach to treat hair loss.
5 citations
,
January 2025 in “Burns & Trauma” This review highlights recent research using single-cell RNA sequencing and machine learning in wound healing, revealing significant insights into fibroblast diversity, immune cell dynamics, and the spatial organization of cells, which may transform therapeutic strategies for chronic wounds, fibrosis, and tissue regeneration.
March 2024 in “BMC cancer” This study reports that high expression of proteins ST14 and TMEFF1 in ovarian cancer correlates with higher tumor malignancy and worse prognosis, and reveals an interaction where ST14 regulates TMEFF1 to promote cancer cell proliferation, migration, and invasion.
June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study developed a comprehensive atlas of human scalp tissue to uncover cell states and lineages in hair follicles, identifying disease-specific cellular changes associated with non-scarring and scarring hair loss, which may offer new diagnostic and therapeutic insights.
January 2026 in “Advances in Clinical and Experimental Medicine” This paper proposes a model integrating regulatory T cells and mesenchymal stem/stromal cells to enhance understanding of peripheral immune tolerance, suggesting their combined roles in immune regulation, autoimmunity pathophysiology, and potential MSC-based therapies.
3 citations
,
November 2015 in “Journal of Investigative Dermatology” This study examines the interaction between androgen receptor signaling and the β-catenin/Wnt signaling pathway in mouse hair follicles, but reports no clinical results.
This study found that γδ T cells play a role in regulating stromal behavior, influencing the composition and vascularity of fibrotic tissues during the foreign body response.
June 2026 in “Nature Communications” This study found that in stretch-mediated tissue expansion, fibroblasts adopt an embryonic-like, low-collagen state that enhances epidermal stem cell renewal, supporting coordinated skin expansion crucial for reconstructive surgeries.
September 2016 in “Journal of thoracic and cardiovascular surgery/The Journal of thoracic and cardiovascular surgery/The journal of thoracic and cardiovascular surgery” This article discusses advancements in heart tissue engineering, emphasizing the importance of environmental signals for cardiomyocyte survival and growth, but reports no new clinical findings.
4 citations
,
May 2025 in “Life” This review highlights advancements in 3D bioprinting for skin tissue engineering, focusing on exosome-loaded bioinks that show potential for enhancing skin regeneration and repair.
134 citations
,
October 2020 in “Preprints.org” This review discusses recent advancements in platelet-rich plasma therapies for tissue repair and regenerative medicine, but reports no new clinical results, highlighting a need for translating research into human clinical protocols.
125 citations
,
March 2017 in “Micromachines” This review highlights recent advancements in microfluidics for 3D tissue model generation and discusses its applications in tissue engineering and high-throughput drug screening without reporting new experimental results.
39 citations
,
April 2023 in “Science Advances” This study identified that bone marrow-derived CD34+ cells act as fibroblast progenitors to enhance tissue regeneration in ischemic limbs by promoting angiogenesis through interactions with macrophages.
16 citations
,
February 2013 in “Molecular Medicine Reports” This study found that CD34+ cells from adipose tissue may enhance hair morphogenesis and participate in blood vessel formation in reconstituted skin tissues of mice.
In this review of autonomous robotic surgery, the authors explore the integration of AI and machine learning in surgical procedures, detailing both the advancements and challenges of these technologies, including ethical concerns and current regulatory frameworks.
12 citations
,
November 2015 in “Cell Death & Differentiation” This study found that immune cells, including T cells and macrophages, significantly influence stem cell behavior and tissue regeneration by secreting cytokines and inflammatory factors in mice.
2 citations
,
March 2019 in “Journal of Histochemistry and Cytochemistry” This study found that NNAT is localized in both undifferentiated and differentiated cells across various rat tissues and has cell-specific intracellular localization, suggesting distinct functional roles.
29 citations
,
November 1975 in “Clinics in endocrinology and metabolism” This article discusses the synthesis and action of testosterone and its interaction with specific receptors, reporting no new research findings.
April 2024 in “Journal of composites science” This review details how hydrogel composites play crucial roles in regenerative medicine, tissue engineering, and drug delivery systems, highlighting innovations in these applications and addressing challenges like bioactivity, biomechanical compatibility, and controlled drug release.
29 citations
,
May 2025 in “Polymers” This study systematically examines how smart biomaterials used with DLP technology can enhance bioprinting in tissue engineering and regenerative medicine, while also identifying current challenges and future research needs.
1 citations
,
December 2023 in “Life” This article discusses the potential role of telocytes in skin regeneration and the need to understand their interaction with platelet-rich plasma, reporting no new experimental results.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study suggests that 3D bioprinting may become a practical solution for tissue regeneration and complex wound care, demonstrating improved outcomes over traditional methods in various applications.
321 citations
,
January 2012 in “Cell stem cell” This study identified TGF-β2 as a crucial signal in hair follicle stem cell regeneration, highlighting its role in counteracting BMP signaling to promote tissue regeneration.
19 citations
,
August 2023 in “Experimental & Molecular Medicine” This study found that the CXXC5 protein is overexpressed in diabetic foot ulcer tissues, suppressing wound healing, and that the small molecule KY19334 accelerated healing in diabetic mice by activating the Wnt/β-catenin pathway.
March 2025 in “Frontiers in Cell and Developmental Biology” This study reviewed how neuropeptides and cutaneous innervation play crucial roles in the process of wound healing, suggesting they significantly influence inflammation and tissue repair phases.
26 citations
,
September 2024 in “National Science Review” This review outlines guidelines for designing Janus hydrogel bioadhesives, highlighting their potential to enhance clinical applications in tissue repair and regenerative medicine by mimicking natural biological barriers, although challenges remain in optimizing their asymmetric surface designs.
12 citations
,
September 2024 in “MedComm” This review reports on the principles, applications, and future potential of bioprinting technology in fields like tissue engineering and organ regeneration, highlighting recent advancements and identifying ongoing challenges and future directions that require collaborative efforts to fully realize the technology's capabilities.
156 citations
,
December 2012 in “Cell Stem Cell” This review explores the role of TGF-β superfamily pathways in stem cell environments and their implications for tissue regeneration and cancer development, reporting no new experimental results.
32 citations
,
December 2017 in “Stem Cells Translational Medicine” This review discusses how studying regenerative biology in certain mammalian models could enhance our understanding of complex tissue regeneration, but it reports no new clinical findings.
14 citations
,
July 2021 in “Bioinformatics” This study demonstrates the use of rPanglaoDB, an R package for combining public single-cell datasets, to create the first unbiased transcriptome profile of fibrocytes, revealing their role in tissue healing.