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    Glossary Thyroid Hormone Receptors

    proteins in cells that bind thyroid hormones to regulate genes

    Thyroid Hormone Receptors (THRs) are proteins found in cells that bind to thyroid hormones, which are crucial for regulating metabolism, growth, and development. When thyroid hormones attach to these receptors, they influence the expression of specific genes, thereby affecting various physiological processes. This interaction is essential for maintaining normal metabolic function and can impact conditions like alopecia if disrupted.

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    1. Thyroid hormone receptor β1 is expressed in the human hair follicle 2000 · 111 citations
    2. Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors PloS one · 2014 · 24 citations
    3. Thyroid Hormone Receptor Agonist Promotes Hair Growth in Mice Clinical, Cosmetic and Investigational Dermatology · 2022 · 1 citations
    4. Thyroid hormone action on skin Dermato-endocrinology · 2011 · 44 citations
    5. Thyroid hormone action on skin Current Opinion in Endocrinology, Diabetes and Obesity · 2012 · 30 citations
    6. A Novel Missense Mutation Affecting the Human Hairless Thyroid Receptor Interacting Domain 2 Causes Congenital Atrichia Journal of Investigative Dermatology · 2002 · 26 citations
    7. Expression Profiles of Reproduction- and Thyroid Hormone-Related Transcripts in the Brains of Chemically-Induced Intersex Frogs Sexual Development · 2011 · 24 citations
    8. Cell type‐specific actions of thyroid hormones in nonalcoholic steatohepatitis and liver fibrosis Liver International · 2024 · 3 citations
    9. Potential Therapeutic Uses of Thyroid Hormone Springer eBooks · 2008
    10. Selective Pituitary Resistance to Thyroid Hormone: Clinical Hyperthyroidism with High TSH on Levothyroxine Administration in I-131 Ablated “Graves Disease” Open Journal of Endocrine and Metabolic Diseases · 2022 · 1 citations
    11. Thyroid hormones and androgens differentially regulate gene expression in testes and ovaries of sexually mature Silurana tropicalis General and comparative endocrinology · 2018 · 13 citations
    12. Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones Endocrinology · 2010 · 105 citations
    13. Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone Journal of Investigative Dermatology · 2008 · 90 citations
    14. Thyroid receptor agonists for the treatment of androgenetic alopecia Bioorganic & Medicinal Chemistry Letters · 2009 · 19 citations
    15. The <i>hairless</i> gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor Genes & Development · 2001 · 178 citations
    16. Hairless is a nuclear receptor corepressor essential for skin function Nuclear Receptor Signaling · 2009 · 30 citations
    17. Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes 2013 · 13 citations
    18. Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease Endocrine Related Cancer · 2019 · 25 citations
    19. Hairless: A nuclear receptor corepressor essential for skin function Advances in developmental biology · 2006
    20. Expression of Hypothalamic–Pituitary–Thyroid Axis RelatedGenes in the Human Skin Journal of Investigative Dermatology · 2002 · 155 citations
    21. Alopecia and Thyroid Disease Springer eBooks · 2008
    22. Voice changes in reproductive disorders, thyroid disorders and diabetes: a review Endocrine connections · 2022
    23. Exploring the “Thyroid–Skin Connection”: Concepts, Questions, and Clinical Relevance Journal of Investigative Dermatology · 2009 · 49 citations
    24. Abstract #1182315: Biotin and thyroid function test Endocrine practice · 2022
    25. The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo Journal of Investigative Dermatology · 2016 · 17 citations
    26. Primary hypothyroidism with exuberant dermatological manifestations Anais Brasileiros de Dermatologia · 2020 · 6 citations
    27. The Endocrine Function of the Skin: An Analytical Narrative Apollo medicine · 2023
    28. Analyse de la régulation du gène Hairless et identification des voies de signalisation affectées chez les mutants «bald Mill Hill». HAL (Le Centre pour la Communication Scientifique Directe) · 2008
    29. Molecular Genetic and Endocrine Mechanisms of Hair Growth Hormone Research in Paediatrics · 2003 · 51 citations
    30. Emerging pharmacotherapies for Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2026