June 2017 in “Journal of The American Academy of Dermatology” Most men with lichen planopilaris had it confirmed by biopsy and often had thyroid issues, sexual dysfunction, or prostate cancer, hinting at a link with hormonal problems.
7 citations
,
January 2022 in “Evidence-based complementary and alternative medicine” This study found that ginger supplementation significantly improved persistent hypothyroid symptoms and may aid in weight and lipid profile management in hypothyroid patients with normal TSH levels.
1540 citations
,
October 2008 in “Fertility and Sterility” This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.
178 citations
,
October 2001 in “Genes & Development” This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.
155 citations
,
December 2002 in “Journal of Investigative Dermatology” This study found that thyroid-stimulating hormone receptors are functionally expressed in various skin cells, implying potential physiological and pathological roles in skin, especially in conditions like autoimmune diseases.
100 citations
,
July 2018 in “Journal of The American Academy of Dermatology” This study found that alopecia areata is linked with a higher prevalence of systemic and psychiatric diseases, suggesting that physicians should monitor for these potential comorbidities.
98 citations
,
July 2014 in “Trends in Molecular Medicine” This article discusses the role of human hair follicles in neuroendocrinology and suggests potential new therapeutic targets by examining how neuromediators influence hair growth, pigmentation, and stem cell biology in organ cultures.
90 citations
,
December 2008 in “Journal of Investigative Dermatology” Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.
83 citations
,
May 1999 in “International Journal of Dermatology” Hair loss that spreads out can often fix itself or be treated by finding and handling the cause.
81 citations
,
June 2010 in “Journal of Dermatological Treatment” This review discusses recent advancements in hair rejuvenation strategies and assesses the potential of herbal drugs as safer alternatives, but reports no new clinical results.
67 citations
,
November 2002 in “Journal of The American Academy of Dermatology” This review discusses diagnostic approaches for women with diffuse, nonscarring hair loss and reports no new clinical results.
58 citations
,
November 2020 in “International Journal of Molecular Sciences” This review discusses the relationship between SHBG, NAFLD, and PCOS and reports no new clinical results; the authors highlight low hepatic SHBG production as potentially significant in PCOS pathogenesis.
52 citations
,
October 1999 in “Developmental Dynamics” This study found that the hairless gene in mice has a more extensive role in development than previously thought, as indicated by its expression in various tissues and associated abnormalities in hr/hr mutants.
47 citations
,
December 2019 in “Frontiers in immunology” This study identified a novel G207E STING mutation associated with severe inflammatory symptoms and suggested that common polymorphisms in TMEM173 and IFIH1 may modify the phenotype in affected individuals.
40 citations
,
August 2018 in “Skin appendage disorders” This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.
34 citations
,
March 2015 in “Clinical and Experimental Dermatology” This study observed that patients with pemphigus have a higher incidence of hypothyroidism, inflammatory bowel disease, and diabetes compared to the general population.
31 citations
,
February 2019 in “International Journal of Cosmetic Science” This study found that ultraviolet radiation negatively affects hair follicle functions in human scalp skin, and caffeine application may provide some protective effects against this damage.
30 citations
,
March 2015 in “PLoS ONE” This study found that thyroxine modulates peripheral molecular clock gene expression in human hair follicles, which may have implications for treating clock-related diseases in patients with thyroid dysfunction.
30 citations
,
January 2009 in “Nuclear Receptor Signaling” This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.
24 citations
,
January 2011 in “Sexual Development” This study observed that chemically-induced intersex frogs displayed altered brain mRNA profiles, with finasteride increasing certain hormone-related gene expressions and fadrozole reducing aromatase activity without affecting gene transcript levels.
16 citations
,
January 2006 in “The Aging Male” This review discusses various skin diseases with endocrinological origins and reports no clinical results, highlighting the need for interdisciplinary understanding in diagnosis.
14 citations
,
September 2020 in “Clinical, cosmetic and investigational dermatology” This study found that a hair serum containing amla extract, freeze-dried coconut water, and selenium significantly improved hair growth rate, density, and reduced hair fall among healthy volunteers over 90 days.
14 citations
,
October 2019 in “International Journal of Women's Health” This article discusses the clinical presentation and management challenges of menopausal acne, noting its multifactorial etiology and recommending tailored treatment approaches based on acne severity and associated features, without reporting new clinical results.
13 citations
,
November 2013 in “Journal of Endocrinology/Journal of endocrinology” This study found that the vitamin D receptor, but not its ligand, regulates genes involved in hair cycle progression, suggesting a role in integrating hormone signaling pathways for hair and epidermal functions.
10 citations
,
July 2015 in “Journal of Cosmetic Dermatology” This study found elevated tissue levels of DKK-1 in patients with both androgenetic alopecia and alopecia areata compared to controls, suggesting DKK-1 as a potential therapeutic target for these conditions.
9 citations
,
October 2018 in “Journal of international medical research” This study found no correlation between the extent of frontal fibrosing alopecia and quality of life, but observed a strong association with thyroid disease in affected women.
9 citations
,
July 1995 in “Veterinary Clinics of North America: Small Animal Practice” This review discusses causes of hair loss in cats, highlighting self-inflicted trauma due to flea allergy dermatitis, and presents no new clinical findings.
9 citations
,
June 2018 in “Scientific Reports” This study reported that patients with alopecia areata or alopecia totalis/universalis have a slightly increased overall cancer risk compared to controls, with specific increases in thyroid, bladder, and prostate cancers depending on the alopecia type.
6 citations
,
December 2019 in “BMC Complementary and Alternative Medicine” This study found that the alcohol extract of Vernonia anthelmintica may counteract stress-induced hair follicle growth inhibition in mice, potentially offering a new approach for treating stress-related hair loss.
6 citations
,
October 2012 in “BMJ” This case report describes a 37-year-old woman whose recurrent hair shedding was associated with low iron stores and a miscarriage, with improvements seen after increased iron intake.