113 citations
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November 2017 in “Scientific Reports” This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.
41 citations
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November 2024 in “Molecular Biomedicine” This review discusses the mechanisms and engineering techniques for enhancing the targeted delivery of extracellular vesicles in therapies but reports no new clinical findings; the authors encourage further exploration to advance clinical applications.
18 citations
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December 2020 in “Frontiers in cell and developmental biology” This study found that extracellular vesicles from low-passage dermal papilla cells may activate hair growth by delivering miR-140-5p, which downregulates BMP2 signaling, suggesting potential therapeutic targets for alopecia.
4 citations
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December 2025 in “Frontiers in Immunology” This systematic review of Mendelian randomization studies reports that autoimmune thyroid disease is associated with increased risk for numerous health conditions, including coronary atherosclerosis and rheumatoid arthritis, while decreasing risks for others, such as lung cancer.
3 citations
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January 2016 in “Biotechnology and Bioprocess Engineering” This animal study found that Laminaria japonica mixed with insulin-like growth factor-1 significantly promoted hair growth in mice, suggesting its potential use for treating alopecia pending further clinical trials.
July 2024 in “Frontiers in Pharmacology” This study suggests that pilose antler extracts promote hair regrowth in androgenetic alopecia mice by activating the AKT and Wnt pathways, enhancing hair follicle stem cell proliferation.
June 2020 in “Journal of Investigative Dermatology” This study reported that a treatment serum containing ingredient blends with panthenol, licorice extract, and red clover extract significantly improved hair volume, scalp coverage, and reduced hair breakage over 6 months in individuals with thinning or damaged hair.
December 2019 in “University of Malaya Students Repository” This study found that Soxhlet extraction is more effective at removing the toxin mimosine from Leucaena leucocephala, and mimosine shows promise as a biodiesel additive due to its antioxidative properties.
8 citations
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January 2009 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” This study reports a novel TRbeta gene mutation associated with resistance to thyroid hormone syndrome, which may contribute to various forms of alopecia in the affected family members.
11 citations
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July 2020 in “International Journal of Ayurvedic Medicine” This study identified 26 bioactive compounds in the ethanol extract of Indigofera tinctoria leaves, which are linked to various therapeutic activities, supporting its traditional medicinal use in treating numerous health conditions.
3 citations
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May 2025 in “Cell Death and Disease” This study found that METTL1 is upregulated in papillary thyroid cancer tissues and promotes cancer cell proliferation and metastasis through its tRNA methyltransferase activity.
2 citations
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January 2025 in “Pharmaceutical Research” This article reviews the possible therapeutic activities of Angelica gigas Nakai root extracts and their components, noting their potential effects on neuro-cognitive, metabolic, and other health conditions, and reports no new clinical results.
June 2023 in “jurnal veteriner” In this study, Typhonium flagelliforme leaf-ethanolic extract combined with natural interferon was observed to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and certain protein expressions in carcinogen-induced tumors in female mice, suggesting potential antitumor effects.
1 citations
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January 2023 in “Bioscience Journal” This study found that combining sorafenib with Platycladus orientalis leaf extract effectively suppressed cervical cancer cell growth by increasing tumor suppressor gene expression and reducing anti-apoptotic gene expression, suggesting a potential rationale for further clinical trials.
January 2026 in “E3S Web of Conferences” This study found that silver nanoparticles synthesized using Mitracarpus scaber extract showed potential hepatoprotective and anti-hyperplastic effects in rats, suggesting novel therapeutic strategies for managing liver injury and benign prostatic hyperplasia.
January 2021 in “Journal of cosmetology & trichology” This study assessed Ageratum conyzoides gel's efficacy in reducing hair loss and improving quality of life in adults with pattern baldness, finding that it decreased temporal recession and improved hair-related distress scores, with a significant reduction in 5α-reductase expression and PGD2 release in vitro.
April 2024 in “International journal of clinical trials” In this study, researchers found that a standardized extract of Sesbania grandiflora (SesZen-Bio™) improved hair density and thickness, as well as increased serum ferritin levels, over an 8-week period among participants, suggesting enhanced keratin production and follicle growth.
July 2025 in “Scientific Reports” In this study, researchers identified six novel prognostic biomarkers for bladder cancer and developed a predictive model that effectively stratifies patients into high-risk and low-risk groups based on immune cell infiltration differences and gene expression.
October 2024 in “Journal of the Endocrine Society” A woman experienced fluctuating thyroid conditions and eye disease, but her symptoms improved with treatment.
October 2024 in “Journal of the Endocrine Society” In this case report, a 70-year-old woman with a history of autoimmune hypothyroidism experienced alternating hypothyroidism and hyperthyroidism over a decade, highlighting the potential role of thyrotropin receptor autoantibodies in these fluctuations.
14 citations
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June 2016 in “Pediatric Dermatology” This review discusses the prognosis and treatment options for hair shaft disorders, finding no studies but suggesting some disorders improve with specific treatments like minoxidil and retinoids, while gentle hair care remains essential.
Collagen CLR and placenta extract may help treat diffuse hair loss.
3 citations
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January 2024 in “Liver International” This study by Dr. Manka and colleagues reported that thyroid hormones play a significant role in regulating hepatic stellate cells, influencing liver fibrosis progression via TGFβ signaling. They found that TRα signaling might enhance scar-free tissue regeneration, offering potential pathways for targeted liver fibrosis treatments.
144 citations
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July 2015 in “Clinical, Cosmetic and Investigational Dermatology” This review reports that alopecia areata affects about 2% of people globally and is linked with psychiatric and medical comorbidities, highlighting its significant disease burden.
26 citations
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October 2002 in “Journal of Investigative Dermatology” This study identifies a mutation in the hairless gene that may impact thyroid receptor interaction, contributing to alopecia universalis congenita in an Arab Israeli patient.
22 citations
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September 2000 in “Journal of Investigative Dermatology” This study found that mu-crystallin gene expression in mouse skin is highest during the anagen phase of hair development, suggesting its possible role in hair follicle growth.
5 citations
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October 1984 in “The BMJ” Up to 50% of scalp hair can be lost before it appears thin, and treatment is only needed for hair loss caused by diseases or deficiencies.
1 citations
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May 2022 in “International Journal of Cosmetic Science” This study reports that Edelweiss extract significantly prolonged the anagen phase and increased hair density, suggesting potential as an anti-hair loss treatment.
September 2023 in “Medicine” In this case report, a 41-year-old man with moderate androgenic alopecia showed an increase in hair density and improvements in hair characteristics after using Zimmer aqueous spray containing Zimmer herbal extract powder for 3 months, suggesting its potential as an alternative treatment for hair loss.
3 citations
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January 2019 in “Elsevier eBooks” This article discusses the importance of interpreting laboratory data and performing physical assessments to support pharmacists in clinical decision-making and patient consultations, but reports no new empirical findings.