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This study found that a 3D wound model, the 3DWoundSE, showed improved responsiveness to injury and cytotoxic stimuli compared to an intact 3D skin equivalent, offering a reproducible and ethical alternative to animal models for early wound response assessment in dermatological research and drug development.

A new method was developed to create better skin models for healing and reconstruction.

This study developed finite element models to examine skin's biomechanical properties, finding that structural heterogeneities like Rete ridges and hair follicles create distinct stress and strain patterns that may influence mechanosensation and skin integrity.

This study found that kaempferol increased the proliferation potential of basal epidermal cells in three-dimensional skin models by enhancing integrin expression and altering cell morphology.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

This study found that mouse embryonic fibroblasts better supported the growth and maintenance of LGR5+ epidermal stem cells compared to porcine fetal fibroblasts, under various culture conditions.

This study developed a novel, 3D-printed dissolving microneedle system for delivering minoxidil to treat hair loss, which showed pH-triggered drug release and enhanced hair regrowth in an alopecia mouse model, offering a potentially sustainable and safe transdermal therapy option.

This study explored the development of GelMet, an electrospun hybrid nanofiber scaffold made from gelatin and PEG methacrylate, which demonstrated strong mechanical properties and effectively supported cell growth in vitro, suggesting its potential for skin tissue engineering applications.

This study found that a new SIS-PEG sponge promoted rapid skin defect healing in mice and showed potential for reconstructing reconstituted skin with regenerated hair.

This review discusses the application of confocal laser scanning microscopy for studying nanoparticle interactions with skin and highlights its potential for broad applications, but reports no new experimental findings.

This study found that using 3D Gel-C6S-HA scaffolds seeded with VEGF165-modified rat hair follicle stem cells enhanced angiogenesis and vascularization in tissue-engineered skin, improving wound healing.

This study found that injecting xeno-free, three-dimensional cell masses from human adipose-derived stem cells improved blood perfusion and preserved limb function in mice without causing tumors or toxicity, suggesting potential for treating severe ischemic diseases.

This review highlights the limited research on sebocyte lipid droplets and their proteins despite their role in sebocyte differentiation and potential involvement in skin diseases like acne and alopecia, and reports no new results.

This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.

This review highlights advancements in 3D bioprinting for skin tissue engineering, focusing on exosome-loaded bioinks that show potential for enhancing skin regeneration and repair.

This article reviews the steps and methods involved in preparing skin tissues for three-dimensional volumetric imaging, highlighting its potential to provide detailed insights into skin structure not possible with traditional 2D histology, but reports no new findings.

This study suggests that alkaline phosphatase-regulated expression of CCL5 contributes to the trichogenicity of human dermal papilla spheres.

This study used a 3D bioprinted human lung cancer model in a mouse phantom to demonstrate a selective cytotoxic effect of X-rays on tumor cells, revealing differences from 2D cell models.

This study suggests that keratinocytes derived from hair follicles of patients with atopic dermatitis provide a useful model for investigating AD-related inflammation, as they showed greater expression changes of AD markers when stimulated with type 2 cytokines compared to those from healthy donors.

This study identified eight isoflavone derivatives as potential nonsteroidal inhibitors of rat 5α-reductase using a pharmacophore model in virtual screening.

This review discusses the potential of adipose-derived stem cells for treating vitiligo, hair loss, and chronic wound healing, but reports no new clinical results and suggests the need for further investigation.

This review article summarizes recent advancements in biomimetic scaffolds, highlighting their promise in tissue engineering and personalized medicine, particularly for skin and musculoskeletal system regeneration, while emphasizing the need for more extensive research to ensure their safety for human use.

This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.

This review discusses advancements and challenges in using 3D bioprinting for diabetic foot ulcer treatments, highlighting potential improvements and existing limitations in replicating skin architecture and clinical application.

The study found that balding scalps have more thin hairs and larger oil glands, which might contribute to skin conditions related to hair loss.

This review summarizes the potential of N-acetyl-cysteine in managing diseases linked to redox imbalance, discussing its effects from cellular mechanisms to clinical applications, though further research is suggested for broader use.

This study found that adiponectin significantly enhanced lipid production in human sebaceous glands and may be a potential target for treating conditions with reduced sebum production.

Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.

This study found that a novel 3D in vitro culture condition improved stemness markers and proliferation potential in human dermal stem/progenitor cells compared to traditional 2D methods.

This article discusses the development and research applications of human hair follicle organ culture techniques, highlighting its potential to explore biological processes beyond dermatology.