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This study aimed to identify reliable predictors for the effectiveness of metformin therapy in weight loss and reduction of plasma androgen levels in PCOS women, highlighting the unpredictability of response to treatment.

This article reviews the effects of 5 alpha-reductase inhibitors for treating conditions like male pattern baldness and benign prostatic hyperplasia, noting significant DHT reduction but reports no new clinical results.

This study concluded that catgut embedment combined with moxibustion and bloodletting may be more effective than finasteride for treating androgenic alopecia, possibly due to reductions in testosterone and the testosterone/estradiol ratio.

This review discusses the effects of hormonal treatments on the physical and mental health of transgender individuals, reporting significant reductions in mental health issues following treatment, but calls for more research on long-term and nonbinary outcomes.

This review discusses the therapeutic use of insulin-sensitizing agents in polycystic ovary syndrome, reporting improved ovulation, insulin sensitivity, and reduction of hyperandrogenism, but calls for larger studies to confirm these effects.

This study examined the evolutionary and functional homology of steroid 5α-reductase and DET2 proteins, identifying protists as a common ancestor, and discovered a new subclass DET2-like in plants, potentially involved in polyprenol reduction.

This study found that a combined oral contraceptive containing ethinyl estradiol and desogestrel appeared effective in temporarily treating ovarian hyperandrogenism in adolescents, with reductions in hormone levels and ovarian volume observed.

In this prospective observational study at a tertiary care center in Uttar Pradesh, researchers observed that comprehensive, individualized treatments significantly improved clinical outcomes for South Asian women with PCOS, including reductions in BMI and improvements in insulin sensitivity, ovulation, and pregnancy rates.

This study describes a case in which a 24-year-old woman with PCOS symptoms, including irregular menstruation and excessive hair growth, showed significant improvement in androgen levels, menstrual regularity, and hair reduction after undergoing a nine-month Ayurvedic treatment plan with dietary and lifestyle modifications.

This study found that in Iraqi women with PCOS, those taking vitamin E supplements experienced a significant reduction in androgenic symptoms like hair loss, weight gain, and acne, along with lower levels of certain hormones linked to the condition.

In this study, researchers developed a novel platform for discovering potential hair loss inhibitors by investigating the testosterone/dihydrotestosterone biosynthetic pathway and its regulation through biochemical mechanisms involving 17β-HSD and 3β-HSD, combined with medicinal plant extracts.

In this study, overweight women with polycystic ovarian syndrome who took evening primrose oil for 10 weeks experienced significant reductions in BMI, LDL, and total cholesterol levels, alongside hormonal changes such as decreased LH, FSH, and testosterone levels, and increased estrogen.

This article discusses various causes and treatment options for hirsutism in women, highlighting the effectiveness of cyproterone acetate and the importance of weight reduction, without presenting new research findings.

This study suggests that finasteride at doses of 5 mg/kg BW or higher may adversely affect spermatogenesis and male fertility in NMRI mice.

In this experimental study on Holtzman rats with induced benign prostatic hyperplasia, the researchers observed that the extract of Physalis peruviana (aguaymanto) had a greater therapeutic effect on prostate weight reduction and prostatic epithelium height compared to finasteride and terazosine.

This abstract only provides a list of abbreviations and does not report any new research findings or results.

This study found that spironolactone reduced androgenic hormones in hirsute women but had only marginal effects on hair growth, making it no more advisable than other therapies.

This study found that phenolic extract from Hibiscus rosa-sinensis flowers significantly decreased testosterone, progesterone levels, and androgen receptor expression in male rats over 60 days.

This study found that systemic testosterone exposure in transgender individuals with XX genotype alters skin biology, increasing androgen and estrogen receptor-positive cells, collagen density, and fibronectin expression while reducing immune cells, which could affect surgical outcomes by promoting a male skin phenotype.

This study developed a testosterone-induced androgenetic alopecia model in BALB/c mice, finding that a 0.075 ml testosterone injection best replicated the dermal and hair follicle conditions of AGA patients, providing a promising tool for future drug testing and research into AGA therapies.

This study reports that testosterone requires conversion to DHT and estradiol for its various actions on external genitalia and bone, influencing lean mass, muscle size, strength, and body fat in hypogonadal males.

This study found that combining D-004 with finasteride results in more significant prevention of testosterone-induced prostate enlargement in rats compared to using either treatment alone.

This pilot study suggests that high-dose testosterone plus finasteride improved body composition in men with impaired gait and low to low-normal testosterone after chronic incomplete spinal cord injury.

This study found that a commonly-used DHT enzyme immunoassay shows significant cross-reactivity with testosterone, leading to inaccurate DHT measurements compared to a gold-standard LC–MS/MS method.

This article discusses the genetic and hormonal factors contributing to male pattern hair loss but reports no new experimental results.

This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.

This study found that treatment with leuprolide plus cyclic estrogen/progestin may lead to a faster and greater improvement in hirsutism compared to a standard oral contraceptive regimen.

This study found that spironolactone reduced testosterone production and urinary 17-ketosteroid excretion, leading to a decrease in hair growth rate and a change in hair texture in women.

This study found that treatment with cyproterone acetate and ethinylestradiol in hirsute women reduced testosterone and androstenedione levels, decreased hair growth, and increased cortisol levels without changing catecholamine excretion.

This study found that in women with PCOS, a combination of finasteride and spironolactone significantly improved all health-related quality of life scales and reduced hyperandrogenism within four months, supporting its role alongside lifestyle measures.