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This review evaluates the hormonal, metabolic, and clinical aspects of a male equivalent PCOS syndrome in men and highlights areas where further research is needed, reporting no new empirical findings.

This report presents a rare case of suspected 3β HSD deficiency in an adult female with symptoms like male pattern hair loss and low testosterone, suggesting a non-classical presentation.

This study found that bee venom promoted hair growth in mice and inhibited a key enzyme involved in testosterone conversion, suggesting its potential as a 5α-reductase inhibitor and hair growth promoter.

Early surgery reduces seizure risk in drug-resistant epilepsy; testosterone to DHT conversion doesn't affect muscle anabolism; veterans with PTSD likely to have riskier opioid use; bevacizumab helps in hereditary bleeding disorder.

In this study, researchers found that human ovaries at different life stages biosynthesize both canonical and non-canonical steroid hormones, with fetal ovaries showing higher enzyme activity related to estradiol and testosterone conversion compared to adult tissues.

This study suggests that in human osteoblast-like cells, the 5alpha-reductase type 1 isozyme predominantly catalyzes the conversion of testosterone to DHT, which may play a role in bone homeostasis.

This review explores different types of alopecia, the effects on hair appearance and growth, and the conventional treatments available, including minoxidil and finasteride, along with their side effects and the need for future drug development and potential therapies.

This study found that a novel thiohydantoin derivative, 3a, effectively inhibited androgen receptor activity in LNCaP cells and showed promising in vivo results by reducing testosterone-induced prostate changes, outperforming finasteride in mitigating prostate index and histopathological alterations.

This review discusses the effects and potential benefits of finasteride in treating hirsutism and androgenetic alopecia but reports no new clinical results.

This review highlights the potential of nanocarriers, like liposomes and solid lipid nanoparticles, in improving targeted drug delivery and effectiveness for androgenetic alopecia treatment, while noting the hurdles of clinical trials and regulatory approval for these advanced methods.

This review discusses the potential of nanocarriers like liposomes and nanoparticles to enhance the delivery and efficacy of treatments for androgenetic alopecia, while noting the challenges of clinical translation, such as securing reliable trials and regulatory approval.

In this study, finasteride treatment in men with androgenetic alopecia reduced the expression of caspases in hair follicles to levels similar to those in men with normal scalps.

Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

This review discusses clinical variations, laboratory testing, and treatments for female-pattern alopecia, including finasteride, but reports no new clinical findings; the authors emphasize managing stress and psychological impacts.

This review found that 5α-reductase inhibitors (such as finasteride and dutasteride) effectively reduce prostate size and stabilize hair loss but are associated with sexual dysfunction; they remain essential treatments for BPH and androgenic alopecia, requiring tailored risk-benefit assessments.

This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.

This study found that use of 5-alpha reductase inhibitors for benign prostatic hyperplasia was not associated with an increased risk of hip fracture in men.

Progesterone treatment improved seizures in a woman with menstrual cycle-related epilepsy, but a wrong medication worsened her condition.

This review discusses recent advances in understanding hair growth mechanisms and reviews current and emerging therapies, but it presents no new clinical results.

This article discusses the role of dermal papilla and dermal sheath cells in the hair cycle and reviews finasteride and minoxidil's mechanisms in promoting hair growth, but presents no new clinical findings.

This case report documents a 59-year-old man in Taiwan who developed breast cancer while undergoing finasteride therapy for benign prostate hyperplasia, marking a rare side effect.

This review examines the effects of sex hormones on hair growth and the pathogenesis of related hair disorders, highlighting current management benefits and controversies but reporting no new results.

This study observed that SY red pericarp rice extract promotes hair growth, inhibits 5α-reductase, and enhances hair regeneration in mice, with the extract being safe from cytotoxicity and irritation, indicating its potential as a natural hair growth promoter.

This article explores the hormonal and genetic factors influencing androgenetic alopecia and identifies potential targets for treatment but reports no new clinical findings.

This study found that Puerariae Flos extract inhibited testosterone 5α-reductase and promoted hair growth in mouse models, suggesting its potential use for treating androgenic alopecia.

This review discusses the impact of testosterone therapy on postmenopausal women's sexual function and well-being but notes a lack of long-term safety studies and debates on defining androgen insufficiency.

Testosterone replacement can help menopausal women with various symptoms, but should be used carefully and is not yet officially licensed in the UK for women.

This review discusses the use of anabolic-androgenic steroids in sports and outlines current methods for detecting urinary steroid doping, particularly testosterone, but reports no new experimental findings.

This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.

This study suggests that in SZ95 sebocytes, a pathway for DHT biosynthesis does not require testosterone as an intermediate, potentially impacting the treatment of androgen-sensitive skin conditions.