991 citations
,
January 2011 in “Nature Reviews Endocrinology” This paper reviews the diagnostic criteria, associated morbidities, and possible evolutionary advantages of polycystic ovary syndrome, but does not report any new findings.
151 citations
,
July 2011 in “Archives of Dermatological Research” This review discusses various strategies to enhance drug delivery through the skin barrier, highlighting liposomes as promising carriers for increased dermal concentrations in topical therapies, but reports no new research results.
43 citations
,
May 1986 in “Clinics in Endocrinology and Metabolism” This review examines androgen status in male and female obesity and its influence on the metabolic syndrome, but reports no new clinical results.
28 citations
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February 2016 in “International Journal of Nanomedicine” This study found that freeze-dried finasteride nanoparticles improved the stability, solubility, and in vitro dissolution of the drug, indicating potential benefits for poorly water-soluble drugs.
25 citations
,
June 2012 in “Endocrine” This review discusses emerging concepts in PCOS from the AEPCOS 2010 meeting and reports no clinical findings; it suggests that the transition of care in congenital adrenal hyperplasia could inform PCOS adolescent care.
16 citations
,
February 2018 in “European Journal of Endocrinology” This review discusses the challenges in measuring testosterone for assessing androgen excess in women and emphasizes the importance of quality control in laboratory methods, but it reports no new clinical results.
15 citations
,
November 2017 in “Drug Development and Industrial Pharmacy” This study found that the optimized finasteride-loaded lyophilized tablets using a self-nanoemulsifying drug delivery system improved bioavailability in human volunteers compared to the marketed finasteride product.
15 citations
,
February 2013 in “Pharmaceutical nanotechnology” This study found that invasomes enhanced the iontophoretic transdermal delivery of finasteride in rabbits, increasing AUC and T1/2 compared to oral suspension.
15 citations
,
October 2012 in “InTech eBooks” Niosomes are a promising and effective way to deliver drugs through the skin.
13 citations
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October 2012 in “InTech eBooks” Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.
11 citations
,
October 2018 in “Hormone and Metabolic Research” This study found no difference in bone mineral density between young women with PCOS and age- and BMI-matched controls, but BMI significantly influenced BMD in women with PCOS.
9 citations
,
November 2009 in “Recent Patents on Drug Delivery & Formulation” This review discusses various patent articles on microemulsion carriers in drug delivery systems and reports no new empirical findings.
8 citations
,
January 2018 in “PubMed” The study reported that reducing finasteride particle size significantly improved its cellular permeation through prostate epithelial cells, though it had a lesser impact on systemic pharmacokinetics and tissue distribution in rats.
November 2025 in “Frontiers in Endocrinology” This review examines the potential of apigenin and ellagic acid as adjunct or alternative treatments for PCOS, but reports no new clinical results and highlights the need for further trials to confirm their efficacy and optimize dosing and delivery.
January 2025 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that insulin resistance is common among Pakistani women with PCOS and is independently associated with increased hyperandrogenism, as indicated by correlations with testosterone levels and other androgenic measures.
July 2024 in “ADMET & DMPK” This review discusses the potential for surface-modified nanostructured lipid carriers to enhance hair regrowth by improving drug absorption and stability, focusing on their use with agents like minoxidil and finasteride for hair loss treatment.
October 2023 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that in women with PCOS, insulin resistance is closely associated with hyperandrogenism, indicating it may independently predict increased androgen levels.
This research focused on formulating finasteride, dutasteride, and minoxidil with cyclodextrins to enhance their solubility and skin penetration for topical use, potentially reducing scalp irritation from current alcohol-based preparations.
January 2010 in “Actas Dermo-Sifiliográficas” A woman developed thick gums from everolimus treatment after a kidney transplant.
5 citations
,
March 2001 in “Clinics in Dermatology” This article explores evidence for a rational strategy in the endocrine and metabolic management of patients with excess body hair or scalp loss and reports no new clinical results.
1 citations
,
March 2025 in “Biomedical Journal of Scientific & Technical Research” This publication overview describes the Biomedical Journal of Scientific & Technical Research's rigorous peer review process and their focus on genetic, biomedical, and technical knowledge research within an open access format, but does not report specific study results.
December 2025 in “Ciencia Latina Revista Científica Multidisciplinar” In this systematic review, researchers found that nanotopical systems like nanoparticles and liposomes significantly improved hair density, thickness, and follicular regeneration markers in alopecia treatment, sometimes surpassing traditional therapies like topical minoxidil, though methodological limitations remain such as insufficient long-term clinical trials.
October 2025 in “Carbohydrate Polymer Technologies and Applications” This study investigated improving Finasteride's water solubility using trimethyl-β-cyclodextrin (TM-β-CD) and β-cyclodextrin (β-CD) as carriers, finding that β-CD improved Fin's cumulative release, while TM-β-CD enhanced its solubility, with computational data supporting these outcomes.
October 2025 in “Advanced Healthcare Materials” This study found that using a stevioside-based microneedle patch significantly increased minoxidil's solubility and skin absorption, promoting hair growth in animal models and achieving 67.5% area coverage by day 35, highlighting the potential of this novel delivery system for androgenetic alopecia treatment.
11 citations
,
September 1990 in “Clinical Endocrinology” This study found that girls with prepubertal simple hypertrichosis had significantly higher plasma levels of dihydrotestosterone compared to controls, which does not align with other androgen markers and warrants further investigation.
3 citations
,
January 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study in mice found that topical pumpkin seed oil promoted hair growth and could be a promising alternative treatment for male pattern alopecia.
2 citations
,
February 2025 in “Journal of Nanobiotechnology” In this study, metal-organic frameworks modified with stearic acid were used to deliver cardamonin to hair follicles, significantly promoting hair growth and cell proliferation in testosterone-challenged mice, suggesting potential benefits for androgenic alopecia treatment.
July 2025 in “Materials Today Bio” This study suggests that curcumin-loaded nanoparticles, which activate autophagy and reduce oxidative stress, showed promise in promoting hair growth in an androgenetic alopecia mouse model.
March 2023 in “Translational Andrology and Urology” This review discusses the pharmacology of 5-alpha reductase inhibitors, their expanding clinical indications beyond benign prostatic hyperplasia, and notes unresolved claims about their potential role in SARS-CoV-2.
This review compiles existing information on the pathogenesis of androgenetic alopecia, highlighting its genetic, hormonal, and environmental factors, but reports no new clinical findings.