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    Glossary Tandem Mass Spectrometry

    analyzes molecules by breaking them into fragments twice

    Tandem Mass Spectrometry (MS/MS) is an advanced analytical technique used to identify and quantify molecules in a sample by breaking them into smaller fragments. It involves two stages of mass spectrometry: the first stage isolates the molecule of interest, and the second stage analyzes the fragments produced after the molecule is broken apart. This method is highly sensitive and specific, making it valuable for applications in fields like biochemistry, pharmacology, and environmental science.

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    1. Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry Drug Metabolism and Disposition · 2009 · 18 citations
    2. A liquid chromatography/tandem mass spectrometry method for determination of aristolochic acid‐I in rat plasma Biomedical Chromatography · 2009 · 15 citations
    3. Analytical method for the biomonitoring of bisphenols and parabens by liquid chromatography coupled to tandem mass spectrometry in human hair Ecotoxicology and Environmental Safety · 2022 · 12 citations
    4. Simultaneous determination of androgens and prostaglandins in human urine using ultra-high-performance liquid chromatography–tandem mass spectrometry Journal of Chromatography B · 2019 · 10 citations
    5. Selective and rapid determination of tadalafil and finasteride using solid phase extraction by high performance liquid chromatography and tandem mass spectrometry Journal of Pharmaceutical and Biomedical Analysis · 2018 · 9 citations
    6. Simultaneous Determination of Selected Steroids with Neuroactive Effects in Human Serum by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry ACS Chemical Neuroscience · 2024 · 5 citations
    7. Cyproterone Acetate Quantification in Human Plasma by High-performance Liquid Chromatography Coupled to Atmospheric Pressure Photoionization Tandem Mass Spectrometry Arzneimittelforschung · 2011 · 1 citations
    8. Simultaneous determination of androgens and prostaglandins in human urine using ultra-high-performance liquid chromatography–tandem mass spectrometry 2019
    9. Determination of 13 janus kinase inhibitors in anti-alopecia cosmetics by ultra-high performance liquid chromatography-tandem triple quadrupole composite linear ion trap mass spectrometry Chinese Journal of Chromatography · 2025
    10. Phytochemical analyses of Ziziphus jujuba Mill. var. spinosa seed by ultrahigh performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry Analyst · 2013 · 38 citations
    11. Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride by liquid chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry Acta Pharmaceutica Sinica B · 2012 · 1 citations
    12. Determination of some sex hormones in health supplements by liquid chromatography with tandem mass spectrometry 2023
    13. Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry Analytical and Bioanalytical Chemistry · 2010 · 51 citations
    14. Picogram determination of finasteride in human plasma and semen by high-performance liquid chromatography with atmospheric-pressure chemical-ionization tandem mass spectrometry Journal of Chromatography B: Biomedical Sciences and Applications · 1994 · 45 citations
    15. Revisiting hyper- and hypo-androgenism by tandem mass spectrometry Reviews in endocrine and metabolic disorders · 2013 · 27 citations
    16. Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry Talanta · 2014 · 20 citations
    17. Gas Chromatography Tandem Mass Spectrometry for Biomarkers of Alcohol Abuse in Human Hair Therapeutic Drug Monitoring · 2010 · 18 citations
    18. Studies on the persistence of estradiol benzoate and nortestosterone decanoate in hair of cattle following treatment with growth promoters, determined by ultra-high-performance liquid chromatography–tandem mass spectrometry Journal of Chromatography A · 2009 · 18 citations
    19. Study on dissolution mechanism of cortisol and cortisone from hair matrix with liquid chromatography–tandem mass spectrometry Clinica Chimica Acta · 2013 · 16 citations
    20. Diagnostic Thresholds for Androgen-Producing Tumors or Pathologic Hyperandrogenism in Women by Use of Total Testosterone Concentrations Measured by Liquid Chromatography-Tandem Mass Spectrometry Clinical Chemistry · 2018 · 13 citations
    21. Measurement of steroid hormones by liquid chromatography-tandem mass spectrometry with small amounts of hair Steroids · 2020 · 11 citations
    22. Determination of 19 Steroid Hormones in Human Serum and Urine Using Liquid Chromatography-Tandem Mass Spectrometry Toxics · 2022 · 7 citations
    23. Close correlation between hyperandrogenism and insulin resistance in women with polycystic ovary syndrome—Based on liquid chromatography with tandem mass spectrometry measurements Journal of Clinical Laboratory Analysis · 2018 · 5 citations
    24. Establishing and Verifying a Robust Liquid Chromatography-Tandem Mass Spectrometry Method to Simultaneously Measure Seven Androgens Present in Plasma Samples Separations · 2022 · 3 citations
    25. Analysis of hair steroid hormone concentrations at different parts of the head by liquid chromatography-tandem mass spectrometry Clinica Chimica Acta · 2021 · 3 citations
    26. Determination of finasteride in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry with flow rate gradient European Journal of Drug Metabolism and Pharmacokinetics · 2010 · 2 citations
    27. An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of dehydroepiandrosterone sulfate in human serum and plasma Clinical Chemistry and Laboratory Medicine (CCLM) · 2025 · 1 citations
    28. Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry. Application to a Comparative Pharmacokinetics Study Drug research · 2015 · 1 citations
    29. Ultra-Performance Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry for the Determination of Ketoconazole in Anti-Dandruff Shampoo Analytical Letters · 2014 · 1 citations
    30. An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 5-alpha-dihydrotestosterone in human serum and plasma Clinical Chemistry and Laboratory Medicine (CCLM) · 2026